Immunologic and immunogenetic studies in rheumatic fever and rheumatic heart disease

Indian Journal of Pediatrics
K S ReddyN K Mehra

Abstract

In order to evaluate all the important limbs of the immune system in the same patient population with rheumatic fever (RF) and rheumatic heart disease (RHD) cellular and humoral immune parameters as well as the immunogenetic profile in 265 North Indian patients with RHD were evaluated. They were studied for class in HLA antigens and 165 of them were also evaluated for the class II (DR locus) antigen profile. Data obtained was compared with 400 and 134 healthy controls respectively of the same ethnicity. Humoral immune parameters (Serum immunoglobulins IgG, IgA; Serum complement fractions C3, C4, C3d; circulating immune complexes and B lymphocyte numbers) and cellular immune parameters (total leucocyte and lymphocyte counts; T lymphocyte sub-populations--CD4, CD8 counts; lymphocyte migration inhibition to an extracellular streptococcal antigen, streptolysin 'O') were studied in 23 patients with RF, 21 patients with "inactive" RHD and 20 normal controls. Patients of RHD were noted to have an increased frequency of DR3 (P less than 0.001; Relative risk = 2.3) and a decreased frequency of DR2 (P less than 0.001; Relative risk = 0.3) as compared to the controls. Patients of RF had evidence of an altered regulatory T cell function (i...Continue Reading

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Citations

Jun 17, 2011·Annals of Pediatric Cardiology·Jonathan R Carapetis, Liesl J Zühlke
Jan 24, 2006·International Journal of Immunogenetics·H KudatO Guven
Jun 4, 2014·International Reviews of Immunology·Madeleine W Cunningham
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Dec 30, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Devinder ToorAnuradha Chakraborti
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Nov 25, 2017·Immunologic Research·Devinder Toor, Neha Sharma
Sep 25, 2020·Immunological Investigations·Maheshkumar PoomarimuthuJayalakshmi Mariakuttikan
Nov 17, 2004·Clinical and Experimental Immunology·M D SchafranskiI J T Messias-Reason

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