Immunologic aspects of the prostate

The Prostate
David M LubaroffT Feldbush

Abstract

Our experiments involving the use of the Dunning R3327 adenocarcinoma as an animal model of prostatic cancer as well as clinical studies on the immunocompetence of prostatic cancer patients are described. Utilizing the Dunning tumor, we have demonstrated that this transplantable adenocarcinoma of the rat prostate was similar to human prostatic cancer with respect to its macroscopic and microscopic appearances, growth rate, growth differential in male and female recipients, and some of its metastatic potential. Cryosurgery was capable of destroying the primary tumor as it can in man. Both antibody and cellular immune responses could be produced against antigens associated with the tumor cells. Tumor-bearing rats treated by cryosurgery in combination with BCG were capable of producing an antitumor immunity that protected them from rechallenge. Clinical studies of prostatic cancer patients showed a diminished in vitro immunity, but the responses of the cancer patients were not significantly different from those of patients with benign prostatic disease.

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Citations

Mar 15, 2011·International Journal of Clinical Oncology·Hideji NishidaHiroyuki Tsuchiya
Dec 18, 2013·Immunotherapy·Abhinav Sidana
Dec 21, 2010·Expert Review of Anticancer Therapy·David S FinleyArie S Belldegrun
Sep 18, 2009·Urology·Abhinav SidanaRonald Rodriguez
Mar 23, 2013·BJU International·Nilay M GandhiDonald L Lamm
May 1, 1995·The Journal of Urology·A MoralesI van der Linden
Oct 17, 2009·Cryobiology·A A GageJ G Baust
Dec 17, 2014·Korean journal of urology·Hyung Keun KimSeok Ho Kang
Mar 17, 2005·Breast Cancer Research and Treatment·Michael S SabelAlfred E Chang
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