Abstract
Retrospective studies have reported that the collected and infused autograft absolute lymphocyte count (A-ALC) affects clinical outcomes after autologous peripheral hematopoietic stem cell transplantation (APHSCT). We hypothesized that manipulation of the apheresis machine to target a higher A-ALC dose would translate into prolonged progression-free survival (PFS) in patients with non-Hodgkin lymphoma (NHL) undergoing APHSCT. Between December 2007 and October 2010, we performed a double-blind, phase III, randomized study randomly assigning 122 patients with NHL to undergo collection with the Fenwal Amicus Apheresis system with our standard settings (mononuclear cells offset of 1.5 and RBC offset of 5.0) or at modified settings (mononuclear cells offset of 1.5 and RBC of 6.0). The primary endpoint was PFS. Neither PFS (hazard ratio [HR] of modified to standard, 1.13; 95% confidence interval [CI], .62 to 2.08; P = .70) nor overall survival (OS) (HR modified to standard, .85; 95% CI, .39 to 1.86; P = .68) were found to differ by collection method. Collection of A-ALC between both methods was similar. Both PFS (P = .0025; HR, 2.77; 95% CI, 1.39 to 5.52) and OS (P = .004; HR, 3.38; 95% CI, 1.27 to 9.01) were inferior in patients inf...Continue Reading
References
Jul 27, 2001·Blood·L F PorrataS N Markovic
Jan 10, 2002·Bone Marrow Transplantation·L F PorrataS N Markovic
May 25, 2002·British Journal of Haematology·Luis F PorrataSvetomir N Markovic
Jul 3, 2002·Leukemia·L F PorrataS N Markovic
May 30, 2003·Bone Marrow Transplantation·L N GordanJ S Moreb
Dec 17, 2003·Bone Marrow Transplantation·L F PorrataS N Markovic
Mar 26, 2004·Leukemia·L F PorrataS N Markovic
Apr 27, 2004·Bone Marrow Transplantation·H KimC Suh
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yago NietoRoy B Jones
Jan 28, 2005·Clinical and Experimental Medicine·L F Porrata, S N Markovic
Mar 15, 2006·Bone Marrow Transplantation·C JoaoS N Markovic
Mar 15, 2006·Bone Marrow Transplantation·R KatipamulaJ L Winters
May 19, 2006·Bone Marrow Transplantation·H KimC Suh
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Harmonization Project on Lymphoma
Feb 28, 2007·Hematology·M R BoulasselJ P Routy
Dec 27, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Devendra K HiwaseAnthony P Schwarer
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Luis F PorrataSvetomir N Markovic
Jul 9, 2008·Cytotherapy·D K HiwaseA P Schwarer
Nov 14, 2008·American Journal of Hematology·Elias Hallack AttaVera Lúcia Neves Marra
Sep 9, 2010·Journal of Clinical Apheresis·Edwin A BurgstalerJeffrey L Winters
Dec 4, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Patrick J StiffJohn F DiPersio
Mar 19, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jessica RueffMartin Stern
Apr 5, 2014·Transfusion·Sudhanshu B MulayEapen K Jacob
Citations
Sep 17, 2016·Advances in Hematology·Luis F Porrata
Dec 13, 2017·Journal of Clinical Apheresis·Luis F Porrata
Mar 8, 2019·Leukemia & Lymphoma·Esa JantunenJaakko Valtola
Oct 17, 2017·Bone Marrow Transplantation·A KansagraL F Porrata
May 19, 2020·Leukemia & Lymphoma·Antti TurunenVille Varmavuo
Dec 6, 2018·American Journal of Hematology·Moritz BinderShaji K Kumar
Apr 22, 2017·Journal for Immunotherapy of Cancer·Michael P GustafsonAllan B Dietz
Apr 30, 2021·Bone Marrow Transplantation·Matthew J ReesAndrew Grigg
Jun 7, 2021·Transplantation and Cellular Therapy·Luis F PorrataSvetomir N Markovic