PMID: 6975649Dec 15, 1981Paper

Immunologic characterization and ultrastructural correlations for 125 cases of B- and T-cell leukemias: studies of chronic and acute lymphocytic, prolymphocytic, lymphosarcoma cell and hairy cell leukemia, Sézary's syndrome, and other lymphoid leukemias

Cancer
J W Said, G S Pinkus

Abstract

Peripheral blood from 125 patients (160 specimens) with various types of lymphoid leukemias was evaluated for B- and T-cell markers (E rosettes, C3 and Fc receptors, and surface immunoglobulin). B-cell leukemias (comprised 82% of the series and included chronic lymphocytic leukemia (69/71 cases), acute lymphocytic leukemia (1/18 cases), lymphosarcoma cell leukemia (15/18 cases), prolymphocytic leukemia (one case), plasma cell leukemia (one case), hairy cell leukemia (12/12 cases), and leukemic phase of "histiocytic" lymphoma and Waldenström's macroglobulinemia (one case each). Within the B-cell group, certain leukemias exhibited distinct patterns of lymphocyte surface markers. Three cases of lymphosarcoma cell leukemia revealed both T and B cell markers (E-rosette formation and monoclonal SIg). T-cell leukemias comprised 12% of the series and included chronic lymphocytic leukemia (2/71 cases), acute lymphocytic leukemia (11/18 cases), and Sézary's syndrome (2/2 cases). In eight cases of acute lymphocytic leukemia, the majority of the cells demonstrated no definable markers (non-B, non-T cell type). Ultrastructural studies, performed in selected cases, were correlated with immunologic findings. Distinctive morphologic features w...Continue Reading

References

Mar 1, 1975·American Journal of Clinical Pathology·M W Morris, F R Davey
Dec 1, 1975·The Journal of Clinical Investigation·D A Horwitz, P I Lobo
Mar 1, 1978·Annals of Internal Medicine·A SaxonD W Golde
Jan 1, 1978·Cancer·F R Dick, R D Maca
Mar 1, 1976·Journal of the National Cancer Institute·J C BrouetM Seligmann
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S GuptaF P Siegal
Jan 1, 1975·Journal of the National Cancer Institute·J H LeechR D Collins
Jan 1, 1975·Journal of the National Cancer Institute·A D GlickR D Collins
Aug 4, 1973·Lancet·D CatovskyG Stathopoulos
Oct 1, 1973·The Journal of Clinical Investigation·K A AultE R Unanue
Mar 1, 1974·Cancer·M T ShawR E Nordquist
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·E ShevachI Green
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D Zucker-FranklinF Quagliata
Feb 1, 1972·Cancer·F N Ghadially, L F Skinnider
Aug 1, 1972·The Journal of Clinical Investigation·E M ShevachI Green
Apr 11, 1974·The New England Journal of Medicine·E S JaffeI Green
Aug 10, 1972·The New England Journal of Medicine·A C Aisenberg, K J Bloch
Oct 1, 1974·Cancer·R J Lukes, R D Collins
Jan 25, 1973·The New England Journal of Medicine·W F PiessensW H Churchill
Feb 1, 1974·American Journal of Clinical Pathology·B Schnitzer, L Kass
Feb 1, 1980·American Journal of Clinical Pathology·C R KjeldsbergH Rappaport

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Citations

Mar 1, 1991·British Journal of Haematology·B BainD Catovsky
Jul 1, 1983·The American Journal of Medicine·D M Mintzer, S P Hauptman
Sep 1, 1983·Journal of Clinical Pathology·G T BesleyA E Dewar

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