PMID: 5905242Feb 1, 1966

Immunologic competence of thoracic duct cells. I. Delayed hypersensitivity

The Journal of Experimental Medicine
J E CoeS Lee


Delayed hypersensitivity was produced in donor Lewis rats by sensitization with soluble protein antigens emulsified in complete Freund's adjuvant. Cells of their thoracic duct lymph were collected for varying periods of time and transferred intravenously to isogenic Lewis recipients. With this model the following conclusions were reached: 1. Delayed hypersensitivity was transferred by thoracic duct cells. 2. The longer the drainage of the thoracic duct, the fewer cells were needed to achieve a successful transfer. With continuing drainage the proportion of small lymphocytes decreased and large cells increased. There was, therefore, a better correlation between successful transfer of delayed hypersensitivity and the number of large cells transfused than between positive skin reactions and transfer of small lymphocytes. 3. Prolonged fistula of the thoracic duct did not diminish the skin reaction of sensitized donors to specific antigen. 4. Delayed hypersensitivity was elicited in recipients 3 wk after transfer of sensitized cells. There was evidence that delayed hypersensitivity was enhanced in recipients, possibly because of prior skin testing. 5. Total body X-irradiation abolished the lesions of passively transferred delayed hy...Continue Reading


Nov 17, 1962·Nature·J L GOWANSD M COWEN
Sep 1, 1963·The Journal of Immunology : Official Journal of the American Association of Immunologists·J D FELDMAN, J S NAJARIAN
Sep 1, 1963·The Journal of Experimental Medicine·J S NAJARIAN, J D FELDMAN


May 1, 1970·The American Journal of Anatomy·N A WivelR Asofsky
Nov 1, 1971·The Journal of Experimental Medicine·D G Tubergen, J D FELDMAN
Mar 1, 1974·The Journal of Experimental Medicine·P H LagrangeT E Miller
Jan 1, 1975·The Journal of Experimental Medicine·P H Lagrange, G B Mackaness
Jan 1, 1974·Transplantation Reviews·R V Blanden
Mar 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Neil W Schluger
Jun 1, 1972·Japanese Journal of Medical Science & Biology·K Kanai, E Kondo
Jan 1, 1972·Oral Surgery, Oral Medicine, and Oral Pathology·T Lehner
Apr 18, 1970·Nature·J G Hall, M E Smith
Nov 18, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E J DelormeP Alexander
Jul 1, 1974·Arthritis and Rheumatism·P J ClementsE V Barnett

Related Concepts

Delayed Hypersensitivity
Lymphoid Cells
Effects of Radiation
Hypersensitivity Skin Testing
Thoracic Duct

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