PMID: 4886901Feb 9, 1968Paper
Immunologic defenses against metastases: impairment by excision of an allotransplanted lymphoma
Science
R K GershonK Kondo
Abstract
Hamsters grafted with an allotransplantable lymphoma that does not metastasize develop a state of concomitant immunity which renders them refractory to reinoculation with cells of the same tumor. Removal of the tumor 7 days after transplantation rapidly leads to a decrease in immunity, the production of enhancing antibodies, and the appearance of metastatic deposits which are probably derived from preexisting tumor cells in the blood and lymphoid tissuces.
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