PMID: 6974554Aug 1, 1981Paper

Immunologic effects of hydralazine in hypertensive patients

Arthritis and Rheumatism
A LitwinE V Hess

Abstract

Twenty-seven hypertensive patients (23 blacks, 4 whites) treated with hydralazine had frequent serologic evidence of autoimmunity. However, only 1 patient developed a lupus syndrome. Acetylator phenotype influenced the autoimmune response; slow acetylators had a higher incidence and titers of autoantibodies. The lupus patient not only had high titers of autoantibodies but they were predominantly IgG in contrast to the predominant IgM antibodies found in other slow acetylators. Hydralazine treatment did not alter cell-mediated immune responses and hydralazine antibodies were not detected. However, half the patients tested who received hydralazine had positive lymphoproliferative responses to the drug.

References

Jun 1, 1975·The Journal of Clinical Investigation·R J DeHoratius, R P Messner

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Citations

Feb 1, 1992·Arthritis and Rheumatism·A B MongeyE V Hess
Nov 1, 1993·International Journal of Immunopharmacology·L E AdamsE V Hess
May 24, 2003·Biochimie·Ludmiła WeglarzZofia Jóźwiak
May 3, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Richard D Handy
Sep 30, 1999·Environmental Health Perspectives·E V Hess
Jun 8, 2002·Pharmacogenomics·Peter Meisel
Feb 18, 2011·Molecular Medicine·Christopher M ReillyNilamadhab Mishra
Oct 14, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Y Braun-MoscoviciA M Nahir
Jan 1, 1986·International Journal of Immunopharmacology·D PendeF Indiveri
Jul 1, 1985·Clinical Immunology and Immunopathology·R L RubinE M Tan
Sep 18, 2002·Pediatric Transplantation·Lars PapeGisela Offner
Jun 2, 1988·The New England Journal of Medicine·E Hess

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