PMID: 287402May 31, 1979Paper

Immunologic effects of vinyl chloride in mice

Annals of the New York Academy of Sciences
R P Sharma, P J Gehring


Male CD-1 mice were exposed to 10, 100 or 1000 ppm vinyl chloride (VC) for 2--8 weeks at 6 hr/day, 5 days/week. A slight increase in the spleen weight of mice was noted at the highest exposure level. Spleens were obtained from these animals (4 mice/group after 2, 4, and 8 weeks of exposure) and their lymphocytes cultured in vitro with or without the presence of phytomitogens, phytohemagglutinin (PHA) and pokeweed mitogen (PWM). Relative blast formation and the DNA synthesis was measured by the incorporation of 3H-thymidine in the cultured cells. The response of splenic lymphocytes to the phytomitogens was increased several-fold by VC exposure. The effects were apparent at 1000 ppm VC after 2 weeks of exposure and at all levels of VC exposure after 4--8 weeks. The effects were generally more pronounced at 100 ppm VC exposure than those at 1000 ppm. In vitro culture of splenic lymphocytes from control or VC-exposed mice in the VC atmosphere did not show an enhancement of blast formation. Alteration of VC metabolism during the VC exposure in vivo yielded results that indicated that metabolites of VC may be responsible for the stimulation of lymphocyte transformation observed in splenic cultures.


Jan 31, 1976·Lancet·A F RojasA J Olivari
Apr 17, 1976·British Medical Journal·A M WardC S Darke
Feb 1, 1977·Cancer·S A Wilkins, Z L Olkowski
Jun 1, 1978·Toxicology and Applied Pharmacology·P G WatanabeP J Gehring
Jun 1, 1976·Annals of Internal Medicine·P D BerkL Thomas
May 1, 1976·Toxicology and Applied Pharmacology·P G WatanabeP J Gehring
Aug 1, 1972·Cellular Immunology·J AnderssonO Sjöberg
Mar 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·G D StockmanJ J Trentin
Sep 16, 1967·British Medical Journal·D K Harris, W G Adams


Jan 1, 1980·International Journal of Immunopharmacology·R P SharmaP J Gehring
Feb 1, 1987·Toxicology·R V ReddyR P Sharma
Jan 1, 1989·Toxicology·R V Reddy, R P Sharma
Sep 11, 1992·European Journal of Pharmacology·G C HsiehR A Coulombe
Jun 1, 1981·Environmental Health Perspectives·J B Silkworth, L D Loose
Mar 1, 1988·Archives of Environmental Contamination and Toxicology·G C HsiehR D Parker
Jul 1, 1987·International Journal of Dermatology·L CzirjákG Y Szegedi
Jan 1, 1980·Journal of Immunopharmacology·R P Sharma, M G Zeeman
May 1, 1986·Angiology·N MagnavitaG Giuliano
Jan 1, 1987·Journal of Toxicology and Environmental Health·B SrisuchartR P Sharma
Jan 1, 1981·American Journal of Industrial Medicine·R P SharmaS A Christensen
Jan 1, 1981·Journal of Immunopharmacology·R P SharmaP J Gehring
Jan 1, 1983·International Archives of Occupational and Environmental Health·H Langauer-LewowickaT Wocka-Marek

Related Concepts

Dose-Response Relationship, Drug
Lymphocyte Activation
Vinyl Chloride
Vinyl Compounds
Animal Lectins

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