Immunologic evaluation of 10 different adjuvants for use in vaccines for chickens against highly pathogenic avian influenza virus

Vaccine
Nazir Ahmed LoneDarrell R Kapczynski

Abstract

Avian influenza viruses (AIV) are a threat to poultry production worldwide. Vaccination is utilized as a component of control programs for both high pathogenicity (HP) and low pathogenicity (LP) AIV. Over 95% of all AIV vaccine used in poultry are inactivated, adjuvanted products. To identify the best formulations for chickens, vaccines were prepared with beta-propiolactone (BPL) inactivated A/British Columbia/314514-1/2004 H7N3 LP AIV using ten commercially available or experimental adjuvants. Each vaccine formulation was evaluated for immunogenicity in chickens. Challenge studies with an antigenically homologous strain of HPAIV were conducted to compare protection against mortality and measure reductions in virus levels in oral swabs. The four best adjuvants from the studies with BPL inactivated antigen were selected and tested identically, but with vaccines prepared from formalin inactivated virus. Mineral and vegetable oil based adjuvants generally induced the highest antibody titers with 100% seroconversion by 3weeks post vaccination. Chitosan induced positive antibody titers in 100% of the chickens, but the titers were significantly lower than those of most of the oil based adjuvants. Antibody levels from calcium phosphat...Continue Reading

Citations

Sep 2, 2017·Journal of Veterinary Science·Dong-Hun LeeDavid E Swayne
Nov 12, 2018·Transboundary and Emerging Diseases·Alan B FranklinThomas J Deliberto
Feb 23, 2018·Frontiers in Microbiology·Daniela S Rajão, Daniel R Pérez
Nov 25, 2020·Vaccines·Nathaniel Nyakaat NinyioAbdul Razak Mariatulqabtiah
Aug 29, 2021·Viruses·Sergio Montaner-TarbesHernando Del Portillo
Jun 9, 2021·Journal of Applied Microbiology·Mohammad Fatemi Motlagh, S Latif Mousavi Gargari
Dec 21, 2021·Frontiers in Veterinary Science·Eun-Seo LeeJong-Soo Lee

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