Immunologic evaluation of children with homozygous beta-thalassemia treated with desferrioxamine

Acta Haematologica
C P SpeerW Schröter

Abstract

In 15 children with thalassemia major (age 4-17 years) a detailed analysis of different immune functions was performed: phagocyte function, specific cellular immunity, humoral defense system. All patients had been subjected to a desferrioxamine therapy and a high transfusion regimen. Examination of neutrophil function included adherence, random migration, chemotaxis, killing of Escherichi coli and production of superoxide radical; these neutrophil functions were shown to be normal. In addition, lymphocyte proliferation in response to different lectins (phytohemagglutinin, concanavalin A, pokeweed mitogen) was identical in patients and controls. However, the number of circulating T-lymphocytes, helper T-cells and B-lymphocytes was increased in some patients. This phenomenon probably reflects an unspecific stimulation of the antibody-producing cells by repeated blood transfusions.

Citations

Dec 29, 2000·Journal of Pediatric Hematology/oncology·W Wanachiwanawin
Sep 1, 1993·British Journal of Haematology·Y MatznerE A Rachmilewitz
Mar 1, 1997·Pediatric Hematology and Oncology·N KutukculerS Caglayan
May 1, 1996·Pediatric Hematology and Oncology·N KutukculerS Caglayan
Sep 12, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Nattiya TeawtrakulChinadol Wanitpongpun
Mar 24, 2006·The Lancet Infectious Diseases·Sandro VentoFrancesco Cesario
Oct 12, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Kovit PattanapanyasatSakorn Kaewmoon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.