Abstract
Cefotetan is a commonly prescribed second-generation cephalosporin that acts against a wide range of bacteria. However, cefotetan-induced hypersensitivity has rarely been reported. We report 2 cases of cefotetan-induced anaphylaxis with immunologic evaluation. The first case was a 70-year-old asthmatic woman who had dyspnea and hypotension during administration of cefotetan, in which high serum-specific IgE to cefotetan-human serum albumin (HSA) conjugate was detected by enzyme-linked immunosorbent assay. The second case was a 63-year-old asthmatic woman who complained of chest tightness and dyspnea during cefotetan infusion, in which high serum-specific IgG1 and IgG4 with no serum specific IgE to cefotetan-HSA conjugate was detected. The basophil activation test using basophils from the patient showed a significant up-regulation of CD63 with the addition of anti-IgG4 antibody compared with that in non-atopic healthy controls. In conclusion, cefotetan can induce anaphylaxis, which may involve both IgE- and IgG4-mediated responses in the pathogenic mechanism.
References
Apr 2, 1979·Allergy·P de HaanG L Kalsbeek
Mar 1, 1990·Clinical and Experimental Immunology·A IshizakaS Matsumoto
Jul 1, 1988·American Journal of Obstetrics and Gynecology·R J Bloomberg
Jan 1, 1984·Antimicrobial Agents and Chemotherapy·N F AdkinsonA A Sugerman
Jul 9, 2003·The Journal of Allergy and Clinical Immunology·Yu-Jin SuhHae-Sim Park
Sep 17, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A RomanoJ-L Guéant
Oct 5, 2006·Current Pharmaceutical Design·C AntúnezM Blanca
Sep 4, 2007·The Journal of Allergy and Clinical Immunology·Fred D Finkelman
Mar 18, 2008·Immunity·Yusuke TsujimuraHajime Karasuyama
Jun 2, 2009·Current Opinion in Allergy and Clinical Immunology·María L SanzCristobalina Mayorga
Jul 1, 2009·Immunology and Allergy Clinics of North America·Oliver V HausmannDidier G Ebo
Jul 2, 2010·Allergy, Asthma & Immunology Research·Joo-Hee KimHae-Sim Park
Mar 2, 2012·Allergy, Asthma & Immunology Research·Jeong-Eun KimHae-Sim Park
Nov 21, 2012·Journal of Korean Medical Science·Young-Hee NamHae-Sim Park
Nov 2, 2013·The World Allergy Organization Journal·Mario Sánchez-BorgesMaria José Torres Jaén
Citations
Jun 2, 2015·Journal of Korean Medical Science·Yoo Seob ShinHae-Sim Park
May 3, 2016·Contact Dermatitis·Ji Hye KimYoo Seob Shin
Aug 1, 2017·Korean Journal of Critical Care Medicine·Ji Hye KimHae-Sim Park
Aug 14, 2021·Computers in Biology and Medicine·Neelam SharmaGajendra P S Raghava