Immunologic evaluation of patients with recurrent ear, nose, and throat infections

American Journal of Otolaryngology
Asghar AghamohammadiAmir Arvin Sazgar

Abstract

In this study, we aimed to study the frequency of possible underlying immunodeficiency responsible for susceptibility to ear, nose, and throat (ENT) infection. One hundred three (72 males and 31 females) consecutive children and adult patients with history of recurrent or chronic ENT infections, referred by otolaryngologists to the Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences (Tehran, Iran), were enrolled to the study from March 2003 to March 2006. For each patient, demographic information and medical histories of any ENT infections were collected by reviewing the patient's records. We measured immunoglobulin isotype concentrations and immunoglobulin (Ig) G subclasses by nephelometry and enzyme-linked immunosorbent assay methods, respectively. Of 103 patients, 75 received unconjugated pneumococcus polyvalent vaccine, and blood samples were taken before and 21 days after vaccination. Specific antibodies against whole pneumococcal antigens were measured using enzyme-linked immunosorbent assay method. Existence of bronchiectasis was confirmed in each patient using high resolution computed tomography scan. Among 103 patients, 17 (16.5%) patients were diagnosed to ha...Continue Reading

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Citations

Nov 19, 2013·Journal of Clinical Immunology·Beatriz Tavares Costa-CarvalhoAntonio Condino-Neto
Jan 8, 2016·Journal of Clinical Immunology·Jonas F LudvigssonLennart Hammarström
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Jan 6, 2015·Expert Review of Clinical Immunology·Hassan AbolhassaniAsghar Aghamohammadi
Apr 4, 2021·American Journal of Otolaryngology·Chadi A MakaryHassan Ramadan

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