Immunologic function in horses after non-specific immunostimulant administration

Veterinary Immunology and Immunopathology
M J FlaminioW Shuman

Abstract

Inactivated Propionibacterium acnes is a biologic response modifier for treatment of non-specific respiratory disease in horses. The objectives of this investigation were to determine alterations in phagocytic activity, phenotypic expression of lymphocyte subpopulations and lymphokine-activated killing cell response in healthy young horses. Samples were collected on day 0, 7 and 14 of the investigation. Blood samples were obtained via jugular venipuncture and pulmonary leukocytes were recovered via bronchoalveolar lavage (BAL). Commercially available P. acnes (Eqstim) was administered intravenously on days 7, 9 and 11 of the investigation. Fever was observed on days 8 and 10, indicating immune reaction. Total peripheral blood white cell count was increased (P < 0.05) on day 14 after P. acnes administration compared to values on days 0 and 7. Total BAL fluid cell count decreased (P < 0.01) on day 14 compared to values on days 0 and 7, which was characterized by a decrease in total lymphocyte (P < 0.01) and macrophage (P < 0.01) counts. The proportion of lymphocytes in BAL fluid decreased (P < 0.005) on day 14 compared to values on days 0 and 7, and the proportion of macrophages increased (P < 0.005) on day 14 compared to values ...Continue Reading

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Citations

Mar 14, 2000·Veterinary Immunology and Immunopathology·M J FlaminioM J Wilkerson
Oct 13, 2006·Current Opinion in Infectious Diseases·E Ingham
Aug 21, 2003·American Journal of Veterinary Research·Sharon WitonskyS Ansar Ahmed
Nov 16, 2004·Veterinary Immunology and Immunopathology·M Julia B F FlaminioDouglas F Antczak
May 16, 2009·Developmental and Comparative Immunology·Rebecca L TallmadgeM Julia B F Flaminio
Dec 3, 2016·The Journal of General Virology·Zelalem H MekuriaCarol A Hartley
Sep 1, 2006·Clinical and Vaccine Immunology : CVI·Hyecheong KooYong Ho Park
May 31, 2020·Journal of Medical Virology·Beniamino PalmieriClaudio Cermelli
Dec 16, 2020·Animals : an Open Access Journal From MDPI·Aleksandra ZygmuntowiczWłodzimierz Markiewicz

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