Immunologic graft reactions after allogenic penetrating keratoplasty

American Journal of Ophthalmology
Jost B JonasWido M Budde

Abstract

To evaluate frequency and risk factors of immunologic graft reactions after allogenic penetrating keratoplasty. Interventional comparative nonrandomized clinical trial. The setting took place in a university eye hospital. The retrospective study included 338 patients (338 eyes). The patients underwent penetrating keratoplasty performed by a single surgeon in the study period from 1989 to 1997. Follow-up period had to be longer than 12 months (mean +/- SD, 31.4 +/- 18.8 months). Frequency of immunologic graft reactions characterized by relatively few small monomorph whitish cells in the anterior chamber, almost no flare, and retrocorneal cellular precipitates. Immunologic graft reactions were detected in 46 patients (46/338 = 13.6%). Statistically significant risk factors for the development of graft reactions were loosening of sutures (P =.046), and preoperative and postoperative corneal vascularization (P =.04). Frequency of an immunologic graft reaction was statistically independent (P >.05) of the graft diameters used in the present study, age, and gender of the patients, HLA-typing, donor age, and preservation data of the donor material. Seventy-four percent (34/46) of all graft reactions were detected within the first 2.5 ...Continue Reading

References

Mar 1, 1991·The British Journal of Ophthalmology·K W Sharif, T A Casey
Jan 1, 1990·Eye·C M KirknessN S Rice
Jan 1, 1995·Eye·G O Naumann
Aug 1, 1997·The British Journal of Ophthalmology·A VailW J Armitage
Oct 30, 1998·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·B SeitzG O Naumann

❮ Previous
Next ❯

Citations

Apr 13, 2013·Middle East African Journal of Ophthalmology·Pho Nguyen, Samuel C Yiu
Oct 24, 2007·Transplantation Proceedings·D SellamiJ Feki
Jun 19, 2007·Survey of Ophthalmology·Anita PandaSatya Priya
Mar 21, 2007·Ophthalmology·Michael D WagonerM Bridget Zimmerman
May 18, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y TanV L Perez
Feb 7, 2006·American Journal of Ophthalmology·Alan Sugar
Jan 19, 2015·Ophthalmology·Korine van DijkGerrit R J Melles
Mar 20, 2012·Expert Opinion on Pharmacotherapy·Mohammed ZiaeiBita Manzouri
Jan 9, 2003·Expert Opinion on Investigational Drugs·Sanjiv Banerjee, Andrew D Dick
Jan 21, 2015·Progress in Retinal and Eye Research·T H van EssenM J Jager
Jul 17, 2016·American Journal of Ophthalmology·Jay J MeyerCharles N J McGhee
Aug 4, 2004·Ophthalmology·Michael SimonNavid Ardjomand
Jan 1, 2016·Vestnik oftalmologii·S V TrufanovD A Krakhmaleva
Dec 12, 2017·Cornea·Alexandra Z CrawfordCharles N McGhee
Mar 7, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Wen-Lei FeiShi-You Zhou
Nov 30, 2006·Cornea·Andrew J EpsteinChristopher J Rapuano
Sep 26, 2007·Cornea·Bruce D S AllanMargareta Claesson
May 18, 2007·International Ophthalmology·Ilse ClaerhoutPhilippe Kestelyn
May 9, 2008·Eye & Contact Lens·Zeynep OzbekChristopher J Rapuano
Sep 24, 2010·International Ophthalmology·Alex W CohenMichael D Wagoner
Jan 7, 2009·International Ophthalmology Clinics·Helene Lam, M Reza Dana
Jul 9, 2010·International Ophthalmology Clinics·Maeve O'Doherty, Conor C Murphy
Apr 11, 2012·Cornea·R Doyle StultingUNKNOWN Cornea Donor Study Investigator Group
Sep 28, 2004·Cornea·Philippe TuppinBernard Delbosc
Jul 26, 2003·International Ophthalmology Clinics·Mark A Terry
Apr 28, 2019·Medicine·Rafael Ignacio BarraquerRalph Michael
Mar 10, 2009·Journal of Perioperative Practice·Karen McColgan
Feb 27, 2021·Klinische Monatsblätter für Augenheilkunde·Sonja HeinzelmannThomas Reinhard
Dec 31, 2017·Survey of Ophthalmology·Wei ZhongDimitri T Azar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.