PMID: 6162802Jan 1, 1981Paper

Immunologic histamine release in vitro from the heart and lung of the cynomolgus monkey

International Archives of Allergy and Applied Immunology
B M WeichmanL W Chakrin

Abstract

Immunologic histamine release was evoked from the sensitized fragmented cardiac and pulmonary tissue of the cynomolgus monkey by a reverse anaphylactic reaction. Ventricular and pulmonary tissue released a similar fraction (approximately 6%) of the total tissue histamine when challenged with antihuman IgE, presumably reflecting the 'active' sensitization of the monkey in vivo. Passive sensitization of these tissues in vitro resulted in significantly greater immunologic histamine release in 6 of the 14 ventricles and d a similar fraction (approximately 6%) of the total tissue histamine when challenged with antihuman IgE, presumably reflecting the 'active' sensitization of the monkey in vivo. Passive sensitization of these tissues in vitro resulted in significantly greater immunologic histamine release in 6 of the 14 ventricles and d a similar fraction (approximately 6%) of the total tissue histamine when challenged with antihuman IgE, presumably reflecting the 'active' sensitization of the monkey in vivo. Passive sensitization of these tissues in vitro resulted in significantly greater immunologic histamine release in 6 of the 14 ventricles and in the lungs. The antiallergic compounds, disodium cromoglycate and SK&F 64398, inhib...Continue Reading

Citations

Apr 1, 1988·Agents and Actions·K RydzyńskiW Kuroczyński
Jan 1, 1986·Circulation Research·A A Wolff, R Levi

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.