Immunologic mechanisms of alcoholic liver injury

Seminars in Liver Disease
Geoffrey M ThieleLynell W Klassen

Abstract

Clinically, the association of alcoholic liver disease (ALD) with circulating autoantibodies, hypergammaglobulinemia, antibodies to unique hepatic proteins, and cytotoxic lymphocytes reacting against autologous hepatocytes strongly suggests altered immune regulation with an increased activity toward normal self-proteins (loss of tolerance). Experimentally, there are several immune responses generated specifically recognizing self-proteins that are modified by metabolites of alcohol. These data strongly suggest that immune reactions may play a significant role in inducing and sustaining an inflammatory cascade of tissue damage to the liver. Additional support for this comes from the observation that the histological appearance of livers with ALD is that of a chronic active hepatitis-like inflammatory disease. Therefore, the hypothesis that immune mechanisms are involved in recurrent alcoholic hepatitis, although not summarily proven, is reasonable, supported by clinical and experimental evidence, and the subject of this article.

Citations

Oct 8, 2009·Genes & Nutrition·Emanuele Albano, Matteo Vidali
Mar 23, 2010·Cellular & Molecular Immunology·Fouad LafdilBin Gao
Aug 10, 2011·Nature Reviews. Gastroenterology & Hepatology·José Altamirano, Ramón Bataller
Apr 24, 2009·Seminars in Liver Disease·Wing-Kin SynAnna Mae Diehl
Nov 6, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Martin J J RonisDennis R Petersen
Nov 19, 2008·Fibrogenesis & Tissue Repair·Erica Novo, Maurizio Parola
Mar 18, 2009·World Journal of Gastroenterology : WJG·Courtney S SchaffertGeoffrey M Thiele
Jul 24, 2015·Hepatology International·Pranoti Mandrekar, Aditya Ambade
Jul 24, 2015·Hepatology International·Benita L McVickerCarol A Casey
Jan 10, 2012·International Journal of Hepatology·Emanuele Albano
Mar 8, 2014·World Journal of Gastroenterology : WJG·Byoung-Jin ParkHye-Ree Lee
Dec 19, 2008·Expert Review of Gastroenterology & Hepatology·Emanuele Albano
Feb 14, 2012·Journal of Proteomics·S BekesovaR Goldman
Sep 22, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Soichiro FushimiAkihiro Matsukawa
Aug 4, 2009·Gastroentérologie Clinique Et Biologique·D G Tiniakos
Jun 14, 2008·International Immunopharmacology·Michael J DuryeeGeoffrey M Thiele
Jan 29, 2008·Trends in Molecular Medicine·Matteo VidaliEmanuele Albano
Nov 30, 2007·Molecular Aspects of Medicine·Emanuele Albano
Jun 16, 2007·Life Sciences·Subir Kumar Das, D M Vasudevan
Dec 14, 2005·Alcoholism, Clinical and Experimental Research·Sören V Siegmund, David A Brenner
Aug 10, 2005·Alcoholism, Clinical and Experimental Research·Minoti V ApteManfred V Singer
Aug 10, 2005·Alcoholism, Clinical and Experimental Research·Thomas L FreemanVictor R Preedy
Apr 25, 2009·Alcoholism, Clinical and Experimental Research·Kati KaartinenJukka Mustonen
Jan 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arnaud LemmersJacques Devière
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Eric S OrmanRamon Bataller
Sep 24, 2010·Alcoholism, Clinical and Experimental Research·Geoffrey M ThieleLynell W Klassen
Nov 27, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Chao YeYong-Ping Chen
Jan 9, 2010·Clinical and Experimental Dermatology·Y Futei, K R Chen
May 28, 2014·Revista de gastroenterología de México·M Galicia-Moreno, G Gutiérrez-Reyes
Apr 14, 2016·Hepatology International·Diana ArseneRamon Bataller
Dec 3, 2014·Redox Biology·Salvatore SuttiEmanuele Albano
Sep 17, 2011·Gastroenterology·Bin Gao, Ramon Bataller
Oct 19, 2016·Journal of Digestive Diseases·Byoungjin ParkYong-Jae Lee
Jun 24, 2017·Pharmacology & Therapeutics·Ming-Jiang XuBin Gao
Jul 8, 2011·Digestive Diseases·F ScaglioniS Bellentani
Mar 2, 2006·Digestive Diseases·Soren V SiegmundDavid A Brenner
Aug 23, 2006·The Proceedings of the Nutrition Society·Emanuele Albano
Feb 21, 2019·Human & Experimental Toxicology·I RadicS J Hudomal
Dec 31, 2014·World Journal of Gastroenterology : WJG·Elisabetta CeniAndrea Galli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Roberta RollaEmanuele Albano
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Stephen F StewartDavid E J Jones
American Journal of Physiology. Gastrointestinal and Liver Physiology
Ian N Hines, Michael D Wheeler
© 2021 Meta ULC. All rights reserved