Immunologic parameters in cord blood indicating early-onset sepsis

Biology of the Neonate
T LehrnbecherH B von Stockhausen

Abstract

Different immunologic parameters were measured in cord blood to test their usefulness in the early diagnosis of early onset sepsis. Cord blood levels of circulating intercellular adhesion molecule-1 (cICAM-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) were significantly elevated in septic compared to nonseptic neonates. No significant difference between either population was seen for cord blood C3a and elastase-alpha 1-proteinase inhibitor complex (E alpha 1 PI). Measured concentrations of cICAM-1, IL-6 and IL-8 in fetal and maternal blood did not correlate, indicating that the neonate's response to sepsis is clearly different from the mother. Our data suggest that cord blood measurements of cICAM-1, IL-6 and IL-8 might be useful in identifying neonates with early-onset sepsis.

Citations

Jul 16, 2008·Molecular & Cellular Proteomics : MCP·Stephen F KingsmoreJ David M Edgar
Apr 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P C Ng
Oct 25, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·C S BuhimschiI A Buhimschi
Apr 19, 2005·Expert Review of Molecular Diagnostics·Bruce H Davis
Jun 16, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Eleftheria HatzidakiChristina Giannakopoulou
Aug 21, 2012·Obstetrical & Gynecological Survey·Annemieke C C EversGerard H A Visser
Nov 5, 1997·Journal of Pediatric Hematology/oncology·T LehrnbecherS J Chanock
Sep 23, 2000·The Pediatric Infectious Disease Journal·S Mehr, L W Doyle
Dec 13, 2002·Acta Paediatrica. Supplement·M XanthouJ Sarafidou

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