May 1, 1975

Immunologic phagocytosis by macrophages: effect by stimulation of alpha adrenergic receptors

Revista Brasileira De Pesquisas Médicas E Biológicas
M Q JavierreW A Sassine


Alpha adrenergic stimulating drugs, metaraminol, norepinephrine, phenylephrine, was found to increase, in vitro, immunological phagocytosis by mice peritoneal macrophages. This effect could be inhibited by dibenamine, a blocking agent. The stimulation by alpha adrenergic agents was similar to that caused by drugs that reduce the intracellular levels of cyclic adenosine monophosphate or by drugs that increase the levels of cyclic guanosine monophosphate.

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Mentioned in this Paper

Macrophages, Peritoneal
Cyclic AMP
Adrenergic alpha-Agonists
Norepinephrine Measurement
Androgen-Insensitivity Syndrome
Visceral Peritoneum

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