PMID: 2098067Jan 1, 1990Paper

Immunologic privilege evoked by histoincompatible intracameral retinal transplants

Regional Immunology
L Q Jiang, J W Streilein

Abstract

In order to examine the fate of intraocular retinal transplants, we placed histoincompatible neural retinas from neonatal BALB/c mice into the anterior chamber (AC) or subconjunctival space of eyes of adult C57BL/6 mice. Clinical and histologic examinations revealed that grafts of developing neural retinal tissue placed within the AC acquired a blood supply, and differentiated into histologically recognizable retinal structures; there was no evidence of inflammation or rejection. By contrast, developing neural retinal allografts placed in the subconjunctival space failed to thrive, and were promptly rejected within 8 days. To examine the nature of the systemic immune response of mice bearing intracameral retinal allografts, C57BL/6 mice, bearing neural retinal allografts from BALB/c donors in their AC for 12 days, were tested for delayed hypersensitivity. When ear challenged with (C57BL/6 x BALB/c)F1 spleen cells, these mice failed to mount significant ear swelling responses, whereas a positive control group of C57BL/6 mice that received neonatal BALB/c retinas implanted in the subconjunctival space displayed vigorous BALB/c-specific delayed hypersensitivity. It is pertinent that, shortly after ear challenge with (C57BL/6 x BAL...Continue Reading

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