PMID: 9450241Feb 5, 1998Paper

Immunologic protection against canine heartworm infection

The Journal of Veterinary Medical Science
M YoshidaY Hayashi

Abstract

This study was conducted to evaluate protective efficiency of three different protocols for vaccination in canine heartworm infection. To evaluate the three protocols of immunization, dogs were separately immunized with living larvae; 1) immunization with gamma-attenuated infective larvae, 2) with 50 micrograms/kg ivermectin-abbreviation, and 3) with chemical abbreviation plus Freund's complete adjuvant (FCA). Each group was composed of two dogs. All dogs used for this study were subcutaneously challenged with 100 intact third-stage larvae (L3) various days after the last immunization, and the worms in the pulmonary arteries and the right ventricle of the heart were recovered 17 to 25 weeks post-infection. The numbers and the sexes of the worms were determined. A mean of 38 worms was burdened in the group immunized with irradiated L3, 36 worms in the chemically-abbreviated group, but 15.5 worms in the group with chemical abbreviation plus FCA. The percentages of the protection in the former two groups were nearly 50%, but 72.3% in the group with ivermectin plus FCA. The adjuvant enhanced the protective immunity against L3 challenge. Obvious eosinophilia was observed in both immunized and control dogs except for two dogs. There ...Continue Reading

References

Dec 1, 1989·The American Journal of Tropical Medicine and Hygiene·Y HayashiH Tanaka
Oct 1, 1988·The American Journal of Tropical Medicine and Hygiene·R B GrieveB P Seibert
Jun 1, 1974·Experimental Parasitology·M M WongM J Lavoipierre
Jan 1, 1974·Transactions of the Royal Society of Tropical Medicine and Hygiene·M M Wong
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·M Tanner, N Weiss

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Citations

Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Virginia L TchakoutéAlexander J Trees
Jul 5, 2013·Clinical Microbiology Reviews·C Paul MorrisEdward Mitre
Aug 30, 2000·Veterinary Parasitology·S NogamiK Nakagaki
Dec 22, 2004·Microbiology and Immunology·Sabarinathan RamachandranJames McCarthy

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