Immunologic response to fungus is not universally associated with rhinosinusitis

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Richard R OrlandiLucy Barr

Abstract

Immunologic response to fungal antigens has been cited as an etiologic factor in chronic rhinosinusitis (CRS). Previous work demonstrated a significant cytokine response in CRS patients that did not correlate with an immunoglobulin E (IgE) response. This study was performed in an effort to replicate these findings in a more geographically diverse population. Prospective in vitro study. Two academic tertiary rhinologic practices in Texas and Utah. Serum and peripheral blood monocytes (PBMC) were obtained from 10 CRS patients and seven controls. Total IgE and fungal-specific IgE levels were determined. Cytokine levels were measured after PBMC exposure to Alternaria, Aspergillus, Cladosporium, and Penicillium extracts. Correlations between cytokine responses and presence of CRS as well as IgE and IgG were determined. Interleukin-5 (IL-5) was produced after Alternaria extract exposure in both CRS patients and controls, but the production was heterogenous and did not correlate with the presence of CRS. IL-5 levels after Alternaria extract exposure correlated strongly with levels of Alternaria-specific IgE in both CRS patients and controls. IL-5 production did not correlate with IgG levels. IL-4, IL-13, and interferon-gamma productio...Continue Reading

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Citations

Dec 19, 2012·Current Allergy and Asthma Reports·Kathleen T Montone
Mar 2, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery·Michael N Pakdaman, Amber Luong
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Kathleen T Montone
Oct 12, 2011·Immunological Investigations·Michael N PakdamanAmber Luong
Feb 3, 2016·Head and Neck Pathology·Kathleen T Montone
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Jun 8, 2010·Otolaryngologic Clinics of North America·Richard R Orlandi, Bradley F Marple
Dec 15, 2015·The Journal of Allergy and Clinical Immunology·Daniel L Hamilos
Mar 19, 2013·The Journal of Small Animal Practice·E MercierD Peeters
Aug 24, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Matteo GelardiNicola Principi
Jan 15, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Ling, D L Hamilos
Jul 6, 2015·Current Allergy and Asthma Reports·Kent LamRobert C Kern
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Mar 1, 2015·Medical Mycology·Pratibha KaleArunaloke Chakrabarti
Dec 3, 2013·The Journal of Allergy and Clinical Immunology·Daniel L Hamilos
Feb 24, 2015·Brazilian Journal of Otorhinolaryngology·Wilma T Anselmo-LimaShirley Shizue Nagata Pignatari
Jul 5, 2017·The Laryngoscope·Yi Chen ZhaoAlkis James Psaltis
Jul 26, 2017·International Forum of Allergy & Rhinology·Leah J HauserJustin H Turner
Oct 27, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jens U PonikauEugene B Kern
Oct 27, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Richard R Orlandi, Bradley F Marple
Dec 22, 2011·American Journal of Rhinology & Allergy·Joy Hsu, Anju T Peters
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
Jan 15, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery

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Methods Mentioned

BETA
PMA

Software Mentioned

GraphPad
GraphPad Prism

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