Immunologic responses against hydrolyzed soy protein in dogs with experimentally induced soy hypersensitivity

American Journal of Veterinary Research
Anna PuigdemontAlessandra Fondati

Abstract

To assess whether dogs with experimentally induced type I hypersensitivity against soy protein would respond to soy hydrolysate and develop cutaneous or gastrointestinal tract reactions after intradermal and oral challenge exposure. 12 naïve Beagle pups (9 sensitized and 3 control dogs). 9 dogs were sensitized against soy protein by administration of allergens during a 90-day period. After the sensitization period, serum concentrations of soy-specific IgE were determined and an intradermal test was performed to confirm the dogs were sensitized against soy protein. An intradermal challenge test and an oral challenge test with native and hydrolyzed soy protein were conducted on 6 sensitized and 2 control dogs. High serum concentrations of soy-specific IgE and positive results for the intradermal test were observed for the 9 sensitized dogs after completion of the sesitization process. Sensitized dogs challenge exposed with hydrolyzed soy protein had a reduced inflammatory response after intradermal injection and no clinical response after an oral challenge exposure, compared with responses after intradermal and oral challenge exposure with native soy protein. Soy-sensitized dogs did not respond to oral administration of hydrolyze...Continue Reading

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Citations

Aug 9, 2012·The Veterinary Quarterly·E Z VeenhofV P M G Rutten
Nov 3, 2010·Clinics in Dermatology·Patrick Hensel
Aug 16, 2018·Journal of the American Veterinary Medical Association·Adam J RudinskyValerie J Parker

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