Immunologic study of artificial skin used in the treatment of thermal injuries

The Journal of Burn Care & Rehabilitation
D Michaeli, M McPherson

Abstract

Artificial skin (Integra) has been developed as an effective treatment of full-thickness burns. The material consists of a bovine collagen and chondroitin-6-sulfate dermal matrix with a silicone rubber "epidermal" layer. After burn wound excision, the artificial skin is implanted. Only the temporary silicone rubber epidermal membrane is removed. The dermal collagen matrix is incorporated by the host. Serial serum samples were obtained from patients who had grafts of Integra artificial skin for the determination of the humoral immune response to Integra. Integra artificial skin presents few if any humoral immunologic problems to patients. Increased antibody activity to bovine skin collagen, bovine skin collagen with chondroitin sulfate, and human skin collagen was not considered immunologically significant.

Citations

Dec 1, 1993·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·M A Minor, M K Sanford
Nov 19, 2003·Advanced Drug Delivery Reviews·Judith E O'Grady, Diana M Bordon
Jul 16, 2003·British Journal of Plastic Surgery·R PalaoP Huguet
Jul 12, 2002·Biomaterials·R OphofA M Kuijpers-Jagtman
Apr 1, 1997·The British Journal of Oral & Maxillofacial Surgery·S OmuraK Fujita
Jan 12, 2000·Burns : Journal of the International Society for Burn Injuries·D M CarusoW R Schiller
May 3, 2011·Tissue Engineering. Part a·Hee Seok YangByung-Soo Kim
Jul 12, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Giovanni NicolettiAngela Faga
Feb 1, 1991·Burns : Journal of the International Society for Burn Injuries·J W Davies
Nov 8, 2008·Expert Opinion on Biological Therapy·Raphael Gorodetsky
Oct 1, 1994·Journal of Cellular Biochemistry·I V Yannas
Dec 12, 2012·Advances in Colloid and Interface Science·Vladimir M Gun'koSergey V Mikhalovsky
Jan 3, 2012·The Journal of Hand Surgery·Marco Rizzo
Jun 10, 1998·The Journal of Investigative Dermatology·C C ComptonD P Orgill
Jul 22, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·James J JungGregory H Borschel
Nov 16, 2010·The Surgical Clinics of North America·Markéta Límová
Jul 7, 2007·Clinics in Podiatric Medicine and Surgery·Paul J KimGlenn M Weinraub
Sep 24, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·A K LynnW Bonfield
Jun 26, 2014·Journal of Tissue Engineering and Regenerative Medicine·Giovanni NicolettiPaola Perugini
Mar 14, 1998·Journal of Pediatric Surgery·D O FauzaA Atala
Apr 1, 1991·Clinics in Dermatology·R P Rapini
Jan 10, 2006·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Glenn Silverstein
Sep 1, 2012·Carbohydrate Polymers·A Abou-OkeilMarwa A Ali
Jun 1, 1997·The British Journal of Dermatology·F Berthod, O Damour
Jul 22, 2014·Journal of Wound Care·Brittany J BeharPaul M Glat
Jan 14, 2011·Plastic and Reconstructive Surgery·Kenneth FanRobert S Kirsner
Jan 14, 2011·Plastic and Reconstructive Surgery·Ioannis V YannasJohn F Burke
Aug 10, 2001·Plastic and Reconstructive Surgery·T D ChouH J Wang
Feb 3, 2000·Journal of Biomaterials Applications·A S PanditD S Feldman
Jul 7, 2017·The International Journal of Lower Extremity Wounds·Zoran BarcotVedran Bacalja
Dec 9, 1993·Journal of Intensive Care Medicine·R L SheridanJ F Burke
May 14, 1993·Science·R Langer, J P Vacanti

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