PMID: 3765341Jun 1, 1986Paper

Immunological activation of rainbow trout macrophages induced in vitro by sperm autoantibodies and factors derived from testis sensitised leucocytes

Veterinary Immunology and Immunopathology
C J Secombes

Abstract

Young cultures of rainbow trout macrophages were found to significantly increase in diameter following addition of muramyl dipeptide or of supernatants from testis/FCA sensitised leucocytes incubated with spermatozoa, or a testis extract. However, such supernatants caused little migration inhibition or increase in phagocytosis of spermatozoa by macrophages, whereas opsonization of spermatozoa with anti-sperm serum caused an almost six-fold increase in phagocytosis. These results suggest an interplay between humoral and cell-mediated immune reactions upon macrophages during experimental autoimmunity to the testis in trout.

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Citations

Jan 1, 1986·Developmental and Comparative Immunology·C J Secombes
Jan 1, 1988·Developmental and Comparative Immunology·C J SecombesA H Jeffries
Jan 1, 1989·Developmental and Comparative Immunology·B PłytyczC J Bayne
Jan 1, 1990·Developmental and Comparative Immunology·A J Ainsworth, D X Chen
Jul 2, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·C A OttingerN W Ross

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