PMID: 8471836Feb 1, 1993Paper

Immunological and clinical effects of intramuscular rIFN alpha-2a and low dose subcutaneous rIL-2 in patients with advanced malignant melanoma

Melanoma Research
G CastelloG Comella

Abstract

Fifteen patients with tumour recurrence following radical surgical excision of malignant melanoma were treated with a combination of interferon alpha-2a (rIFN alpha-2a) and interleukin-2 (rIL-2). Immunological monitoring (performed prior to therapy and on days 7, 21, and 28, of each course of treatment) showed significant changes of several parameters after rIFN alpha-2a and rIL-2 administration. A significant increase in cells expressing CD16 (cells bearing Fc receptor), CD25 (cells bearing IL-2 receptor), and CD56 (NK cells, activated lymphocytes), as well in levels of soluble IL-2 receptor, beta 2-microglobulin and neopterin was observed. Immunological changes were closely related to the injection of the biological agent and were more relevant during the first than the second cycle of treatment. rIFN alpha-2a and rIL-2 exerted a clear synergistic activity on the same immunological parameters. No major response was seen with the present approach: four subjects showed rapid progression of decrease during the first month of therapy, while of 11 patients who completed two courses of treatment, only five were considered in stable disease. In conclusion, our results suggest that a combination of rIFN alpha-2a and rIL-2, at dosages...Continue Reading

Citations

May 22, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Barbara FrickDietmar Fuchs
Jun 1, 1996·Annals of Medicine·K Villikka, S Pyrhönen
Jul 1, 1995·Current Problems in Cancer·J I Clark, L M Weiner
Dec 26, 2006·Expert Review of Anticancer Therapy·Henry B Koon, Michael B Atkins
May 30, 2003·Seminars in Cutaneous Medicine and Surgery·Larisa GeskinJohn M Kirkwood

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