PMID: 6987641Jan 1, 1980Paper

Immunological and morphological comparisons in toxic goiter

Problemy e̊ndokrinologii
Iu E LivergantN G Tarikovskaia


Histostructural peculiarities of the toxic goiter tissue were compared with humoral parameters of the autoimmune aggression and with the lymphoblasttransformation intensity in 29 patients operated on for thyrotoxicosis. The intensity of intradermal hypersensitivity reaction of delayed type in response to homologous and autologous tissue of the toxic goiter was also investigated. The majority of the patients displayed marked signs of autoimmune aggression, regardless of the structure of the goiter parenchyma and the intensity of ilt lymphoid infiltration. Immunological disturbances increase with the rise in the clinical severity of thyrotoxicosis. It is suggested that immunological changes of toxic goiter have phasic development. Humoral manifestation of autoimmune aggression were marked and stable, whereas changes of cellular immunity were less significant and specific; they were apparently due to a secondary increase in the lymphocytic immunological activity.

Related Concepts

Antibody Formation
Autoimmune Diseases
Graves Disease
Hemolytic Plaque Technique
Delayed Hypersensitivity
Immediate Hypersensitivity
Cellular Immune Response
Lymphocyte Activation
Thyroid Gland

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Biulleten' eksperimental'noĭ biologii i meditsiny
E P MoskalenkoE N Sologub
Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
F Villegas-AlvarezA Vences-Mejía
Urologii︠a︡ i nefrologii︠a︡
A V RudenkoT V Dem'ianova
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Kristin H HaraldsdóttirK-G Tranberg
© 2021 Meta ULC. All rights reserved