PMID: 11605897Oct 19, 2001Paper

Immunological and toxicological implications of short-term studies in animals of pharmaceutical aerosol delivery to the lungs: relevance to humans

Critical Reviews in Therapeutic Drug Carrier Systems
Anthony J Hickey, L Garcia-Contreras

Abstract

The effects of xenobiotics on the lungs have been studied for many years. In the past 50 years, delivery of drugs to the lungs has been adopted to achieve local effects, specifically for the treatment of asthma. Recently, due to the proximity of the circulating blood supply and to their large surface area, the lungs have been proposed as the port of entry for drugs to obtain systemic effects, particularly for macromolecular compounds of biological origin. Numerous studies regarding drug formulation, delivery systems, and related pharmacokinetics have been reported; however, the concurrent effects of pulmonary delivery of drugs on the physiology of the lung has not been evaluated early in the development process. The prospect of using the lungs for the delivery of biological molecules such as proteins, peptides, and nucleic acids raises the question of the local toxicity of these compounds. Therefore, criteria must be established to study the initial impact of pulmonary drug delivery on the physiology of the lungs. This relates particularly to subtle local and systemic implications of those effects on the transport phenomena that may be contrasted with conventional toxicity studies focused on gross effects.

Citations

Sep 11, 2007·Journal of Pharmaceutical Sciences·Chandan ThomasFakhrul Ahsan
Feb 9, 2007·Journal of Pharmaceutical Sciences·Shuhua BaiFakhrul Ahsan
Mar 2, 2011·Advanced Drug Delivery Reviews·Jenny Ka-Wing LamHak-Kim Chan
Apr 16, 2016·Kona : Powder Science and Technology in Japan·Susanne R Youngren-OrtizMahavir B Chougule
Jul 21, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Shuhua BaiFakhrul Ahsan
May 25, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Alamdar Hussain, Fakhrul Ahsan
Nov 28, 2013·Pharmaceuticals·Yu FujitaTakahiro Ochiya
Feb 16, 2019·BMC Pulmonary Medicine·Martin WallinHak-Kim Chan
Apr 25, 2006·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·G DuscherA Joachim
Apr 18, 2019·Therapeutic Delivery·Rima Kandil, Olivia M Merkel
Apr 19, 2005·Obesity Research·Leonie K HeilbronnEric Ravussin
May 23, 2019·Therapeutic Delivery·Denish BardoliwalaAmbikanandan Misra
Jul 29, 2017·AAPS PharmSciTech·Tülin MorçölTimothy Block

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