Immunological Aspect of Radiation-Induced Pneumonitis, Current Treatment Strategies, and Future Prospects

Frontiers in Immunology
Anup KaintholaPaban K Agrawala

Abstract

Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of treatment and leading to fibrosis later. Several cytokines and inflammatory molecules interplay in the vicinity of the tissue developing radiation injury leading to pneumonitis and fibrosis. While certain cytokines may be exploited as biomarkers, they also appear to be a potent target of intervention at transcriptional level. Initiation and progression of pneumonitis and fibrosis thus are dynamic processes arising after few months to year after irradiation of the lung tissue. Currently, available treatment strategies are challenged by the major dose limiting complications that curtails success of the treatment as well as well being of the patient's future life. Several approaches have been in practice while many other are still being explored to overcome such complications. The current review gives a brief account of the immunological aspects, existing management practices, and suggests possible futuristic approaches.

References

Mar 1, 1977·The British Journal of Radiology·D P Mclnerney, J Bullimore
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R K AssoianM B Sporn
Aug 1, 1995·Chest·J Kobayashi, S Kitamura
Jan 1, 1993·International Review of Experimental Pathology·P F Piguet
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·M S AnscherR L Jirtle
Feb 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J N FinkelsteinP Rubin
Dec 1, 1996·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F M KongM S Anscher
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·M S AnscherR L Jirtle
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·L B MarksM Anscher
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·M V GrahamC A Perez
Aug 5, 2000·International Journal of Radiation Oncology, Biology, Physics·T J RobnettW G McKenna
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·J ArayaM Kobayashi
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·Y ChenP Okunieff
Jun 29, 2001·Current Opinion in Oncology·S H AbidM C Perry
Sep 15, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K GotoY Nishiwaki
Mar 28, 2002·Seminars in Radiation Oncology·Yuhchyau ChenPaul Okunieff
Mar 28, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiroshi OnishiHiroshi Ishihara
May 17, 2003·Science·Monica Garcia-BarrosRichard Kolesnick
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Berrin OzturkMehmet Kitapci
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shawn J SkerrettChristopher B Wilson
Apr 28, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alena Novakova-JiresovaHarry J M Groen
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul OkunieffLynn H Gerber
Sep 21, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Claudia E RübeChristian Rübe
Mar 23, 2005·The Journal of Experimental Medicine·Amir AbdollahiPeter E Huber
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Michael FayDavid Ball
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey D BradleyUNKNOWN Radiation Therapy Oncology Group
Jun 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Ellen D YorkeC Clifton Ling
Oct 6, 2005·Journal of Leukocyte Biology·J M WandsWilli K Born
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominique ArpinChristian Carrie

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Citations

Feb 14, 2019·Oxidative Medicine and Cellular Longevity·Xu WuLei Zhu
Apr 27, 2019·Frontiers in Immunology·Simone de LeveVerena Jendrossek
Dec 20, 2019·Dose-response : a Publication of International Hormesis Society·Yida LiZhengfei Zhu
Dec 24, 2018·International Journal of Molecular Sciences·Florian WirsdörferVerena Jendrossek
Jan 8, 2021·BMC Pulmonary Medicine·Marisol Arroyo-HernándezOscar Arrieta
Nov 5, 2020·Biomedicines·Elena ObradorAlegría Montoro
Jan 17, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·François CousinRoland Hustinx
Oct 30, 2020·Dose-response : a Publication of International Hormesis Society·Xi YangZhengfei Zhu
Mar 3, 2021·Expert Opinion on Drug Safety·Yuji ShibataTerufumi Kato
Sep 16, 2020·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Amit Alok, Paban K Agrawala
Aug 1, 2019·The Lancet Oncology·Eric DeutschGuido Kroemer
May 23, 2021·Journal of Infection and Public Health·Claudia Rita CorsoDaniele Maria-Ferreira
Feb 20, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chengxu MaYingdong Li
Oct 16, 2021·Journal of Molecular Biology·Yinan WeiZhenyu Li

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Methods Mentioned

BETA
bronchoalveolar lavage

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