PMID: 8951805Nov 1, 1996Paper

Immunological aspects of nitric oxide in HIV-1 infection

Medical Hypotheses
D Torre, G Ferrario

Abstract

Nitric oxide is produced in large amounts during host defense and immunological reactions and it is likely to have a role in non-specific immunity: nitric oxide exerts microbiostatic and microbicidal activity against a variety of pathogens, including protozoa, fungi, bacteria and some viruses. HIV-1 stimulates nitric oxide production by human macrophages and its production is increased in patients with HIV-1 infection. It is postulated that nitric oxide may play a part in modulating the immune response during HIV-1 infection. Nitric oxide produced by the HIV-1 infected monocytes/macrophages of lymph nodes, may adversely affect the survival of activated immune cells, including B and T lymphocytes and dendritic cells within their vicinity. It is suggested here that production of large amounts of nitric oxide by macrophages may lead to the inactivation of lymphocytes and thus to the induction of a persistent immunosuppression.

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Citations

Apr 20, 2001·Journal of Virology·J L JiménezM A Muñoz-Fernández
Jun 14, 2002·The Lancet Infectious Diseases·Donato TorreFilippo Speranza
Jul 26, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Elaine Uchima UeharaCyro Alves de Brito
Feb 1, 2014·Free Radical Biology & Medicine·Thangavel SamikkannuMadhavan P N Nair
Jul 8, 1999·The American Journal of Pathology·F ChenL M Demers
Jul 31, 2002·BMC Infectious Diseases·Ajay WanchuSurjit Singh

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