Immunological changes in response to exercise: influence of age, puberty, and gender

Medicine and Science in Sports and Exercise
Brian W TimmonsOded Bar-Or

Abstract

This study tested the hypothesis that exercise-induced perturbation and recovery of the immune system would vary with age, puberty, and gender in healthy children and adolescents. Twelve-year-old girls (YG; N = 14) and boys (YB; N = 20), and 14-yr-old girls (OG; N = 11) and boys (OB; N = 13) cycled for 60 min at 70% VO2max. Blood was collected before, at 30 and 60 min of exercise, and at 30 and 60 min of recovery to measure total leukocytes, leukocyte and lymphocyte subsets, and cytokines. Age and pubertal (Tanner stage) effects within genders and gender effects within age and pubertal groups were determined. Exercise-induced increases in lymphocytes, CD3-CD16+CD56+ counts, and IL-6 were approximately 83, 90, and 390% greater in OG versus YG (P < 0.05). Recovery leukocytosis and neutrophilia were approximately 56 and 35% greater in OB versus YB (P < 0.05). Pubertal stage did not have a statistically significant influence on responses in girls, but the lowest pubertal stage consistently showed smaller changes in lymphocytes and CD3-CD16+CD56+ counts. Recovery neutrophilia was approximately 120% greater in postpubertal boys versus prepubertal or pubertal boys (P < 0.05). Responses of lymphocytes and CD3-CD16+CD56+ counts, respect...Continue Reading

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Citations

Jun 9, 2009·Journal of Endocrinological Investigation·A ErmolaoM Zaccaria
May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Brian W TimmonsMichael C Riddell
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Brian W Timmons, Sandeep Raha
Mar 31, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·José P MorgadoFrancisco Alves
Oct 8, 2008·Journal of Physiological Anthropology·Jung Hee HongIn-Seon Lee
Oct 8, 2008·Journal of Physiological Anthropology·Jung Hee HongIn Seon Lee
Jan 30, 2015·Research in Sports Medicine·Kamal AzizbeigiStephen R Stannard
Sep 10, 2009·Wilderness & Environmental Medicine·Shuhei IzawaKatsuhiko Suzuki
Dec 30, 2006·Brain, Behavior, and Immunity·Brian W Timmons, Oded Bar-Or
Dec 24, 2018·Scandinavian Journal of Medicine & Science in Sports·Karah J DringMary E Nevill
Jun 7, 2007·European Journal of Applied Physiology·Brian W Timmons, Oded Bar-Or
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Feb 15, 2019·Pediatric Exercise Science·Alon EliakimAlex V Rowlands
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Jul 7, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kimberly A VoltermanBrian W Timmons
Jan 10, 2018·European Journal of Applied Physiology·José P MorgadoFrancisco Alves
Feb 2, 2021·Trends in Analytical Chemistry : TRAC·Sharda KotruMatiar M R Howlader

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