May 22, 2001

Immunological characterization of conjugated Haemophilus influenzae type b vaccine failure in infants

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Mijke A BreukelsG T Rijkers


Infant vaccination with conjugated Haemophilus influenzae type b (Hib) vaccine is highly effective in protecting against invasive Hib infections, but vaccine failures do occur. Twenty-one vaccine failures are reported since the introduction of the Hib conjugate vaccine in The Netherlands. Of the 14 evaluable patients, 6 children showed no antibody response to Hib polysaccharide in convalescent-phase serum (immunoglobulin [Ig] G anti-Hib level <1.0 microg/mL), including 1 child with hypogammaglobulinemia and 1 child with IgG2 deficiency. After revaccination, almost all children developed anti-Hib antibodies. In case of Hib vaccine failure, case investigation should be performed, including measurement of serum Ig concentrations as well as specific anti-Hib antibodies. Invasive Hib disease after infant conjugate Hib vaccination may be the presentation of an underlying immunodeficiency, but more often, only a decreased antibody response to Hib is found; revaccination with conjugated Hib vaccine is advised.

Mentioned in this Paper

Haemophilus influenzae a, capsular polysaccharide vaccine
Immunologic Deficiency Syndromes
Meningitis, Haemophilus
Immunoglobulin Activity
Haemophilus Vaccines
Vaccines, Conjugate
Haemophilus influenzae type b polysaccharide vaccine
Polysaccharides, Bacterial

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