PMID: 2107802Jan 1, 1990Paper

Immunological characterization of the Marin County strain of astrovirus

Archives of Virology
J E HerrmannN R Blacklow

Abstract

Marin County virus (MCV) was isolated from a stool suspension and serially propagated in human embryonic kidney cell cultures. MCV particles in stool and cell-propagated virus stocks showed reactivity by immune electron microscopy (IEM) with rabbit antiserum to astrovirus type 5. MCV antigen was also detected in two MCV stool samples by enzyme immunoassay (EIA) with an astrovirus group-specific monoclonal antibody. Acute and convalescent sera from 3 of 3 MCV-infected patients showed seroconversion to cell-propagated MCV by EIA. Immunofluorescence of MCV propagated in cell culture showed positive reactivity with an astrovirus group specific monoclonal antibody and astrovirus type 5 antiserum, with some cross-reactivity with astrovirus type 1. Similar results were obtained with the prototype strain of astrovirus type 5. However, in plaque-reduction assays, both the prototype astrovirus type 5 and MCV were neutralized by type 5 antiserum only. We conclude that MCV can be serially propagated by techniques used for previously described astroviruses and is serotypically an astrovirus type 5.

References

Aug 1, 1979·Journal of Clinical Pathology·W D CubittW Moore
Jan 1, 1989·Archives of Virology·R W HudsonN R Blacklow
Sep 26, 1987·Lancet·J E HerrmannN R Blacklow
Dec 15, 1984·Lancet·J B Kurtz, T W Lee
Dec 1, 1981·The Journal of General Virology·T W Lee, J B Kurtz

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Citations

Aug 1, 1997·Journal of Virological Methods·M B TaylorW D Cubitt
Jun 20, 1991·The New England Journal of Medicine·J E HerrmannN R Blacklow
Sep 1, 1990·Baillière's Clinical Gastroenterology·W D Cubitt
Sep 16, 2008·Comparative Immunology, Microbiology and Infectious Diseases·Enrique Royuela, Alicia Sánchez-Fauquier
Nov 22, 2000·The Journal of General Virology·M Méndez-TossC F Arias
Aug 17, 1999·Journal of Clinical Microbiology·J P BrinkerJ E Herrmann

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