PMID: 5909790Mar 18, 1966

Immunological competence: alteration by whole body x-irradiation and shielding of selected lymphoid tissues

Science
J Miller

Abstract

The spleen and thymus of 6-week-old mice contain similar numbers of lymphoid cells. A lethal dose of x-irradiation given to animials whose thymus, midgut, or hindlimbs were shielded at the same time resulted in permanent acceptance of allografts, while a similar dose given to spleen-shielded mice so irradiated resulted in a normal rejection pattern. The return of immunological competence was related to the state of the lymphoid organs with different types of shielding.

Citations

Nov 7, 1999·Transplantation·J MillerV Esquenazi
Jun 1, 1968·The Annals of Otology, Rhinology, and Laryngology·P E Hermans

Related Concepts

Natural Immunosuppression
Lymph Nodes
Effects of Radiation
Spleen
Thymus Gland
Transplantation Immunology

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