Immunological control of hepatotoxicity and parasite egg excretion in Schistosoma mansoni infections: stage specificity of the reactivity of immune serum in T-cell deprived mice

Transactions of the Royal Society of Tropical Medicine and Hygiene
M DoenhoffO Hassounah

Abstract

Within seven weeks of infection with 200 Schistosoma mansoni cercariae, T-cell deprived mice have been shown to suffer from extensive microvesicular damage to hepatocytes, and an inability to excrete parasite eggs at the same rate as comparably infected, immunologically intact controls. Administration of serum (CIS) from chronically infected, immunologically intact donors prevented the development of microvesicular cell damage and partially restored egg excretion rates in infected deprived mice. Serum pools obtained from mice injected either with intact S. mansoni eggs or with a homogenate of eggs emulsified in Freund's complete adjuvant (FCA) were as effective as CIS in preventing hepatotoxicity and restoring the rate of egg excretion in infected deprived recipients. The degree of protection of liver tissue afforded by immune sera could be monitored either by histopathological examination of liver sections or by estimation of serum transaminase concentrations, the results from both assays being generally in agreement. Sera from donor mice injected with cercarial or worm antigens in FCA were relatively inactive either in protecting against S. mansoni-induced liver damage or in reconstituting egg excretion rates in infected depr...Continue Reading

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Citations

Dec 1, 1990·Cancer Metastasis Reviews·M J DoenhoffJ Modha
Nov 10, 2012·Seminars in Immunopathology·Keke FairfaxEdward J Pearce
May 1, 1996·International Journal for Parasitology·P G FallonJ M Behnke
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·D W DunneM J Doenhoff
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·D W DunneM J Doenhoff
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffS Lucas
Nov 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·A J SimpsonF Rumjanek
Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·M U IwobiR A Neal
Jan 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffJ Bain
Apr 1, 1992·Molecular and Biochemical Parasitology·D MoserM Q Klinkert
Dec 1, 1990·Parasitology Today·E Linder
Nov 7, 1999·Molecular and Biochemical Parasitology·M WuhrerR Geyer
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Jun 13, 2002·Parasite Immunology·Frederik De JongeJean-Pierre Timmermans
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Sep 7, 2005·Molecular and Biochemical Parasitology·Colin M FitzsimmonsDavid W Dunne
Jun 21, 2005·Experimental Parasitology·José Roberto Machado-SilvaAntonio Carlos da Silva

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