Immunological dysfunction in chronic arsenic exposure: From subclinical condition to skin cancer

The Journal of Dermatology
Sebastian YuHsin-Su Yu

Abstract

Exposure to arsenic is a global health issue. Long-term arsenic exposure may associate with various cancers and many other pathological effects. Over 100 million people worldwide are exposed to arsenic particularly in countries such as Bangladesh, Chile, China, India, Mexico, Taiwan and the USA. Drinking of water contaminated with arsenic is the major route of human exposure. Skin lesions are considered to be the most common adverse effects associated with chronic arsenic exposure. Skin lesions usually develop with the latency period spanning more than 20 years from first exposure. Arsenic-induced Bowen's disease, the most frequently encountered carcinoma in situ resulting from chronic arsenic exposure, is characterized by multiple and recrudescent lesions. Long-term arsenic exposure results in impaired immunity in susceptible individuals. In the prenatal stage, enhanced placental inflammatory responses and reduced placental T cells by arsenic may result in decreased thymic size and functions in newborns. In childhood, arsenic exposure may reduce peripheral CD4+ cells and interleukin-2 secretion which leads to susceptibility to opportunistic infections. There was an impairment of macrophage function and oxidative DNA damage of ...Continue Reading

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Citations

May 11, 2019·Cutaneous and Ocular Toxicology·Afrooz SaadatzadehSeyyed Mohammad Ali Noori
Aug 4, 2019·International Journal of Environmental Research and Public Health·Hsin-Wei HuangHsin-Su Yu
Nov 11, 2019·Journal of Immunotoxicology·Faruque ParvezRubhana Raqib
Jun 24, 2020·Journal of Hazardous Materials·Afsane BahramiAmirhossein Sahebkar
Oct 17, 2020·Human & Experimental Toxicology·Md Monirul Islam, Naoshi Takeyama
Apr 27, 2021·The American Journal of Dermatopathology·Akemi MaedaYasuhiro Fujisawa
Sep 3, 2021·Scientific Reports·Sebastian YuChien-Hui Hong
Oct 26, 2021·Leukemia & Lymphoma·Cristina M GhiuzeliRadhika Dhingra
Nov 4, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mayukh BanerjeeJ Christopher States

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