Immunological dysfunction in schizophrenia: a systematic approach

Neuropsychobiology
M RothermundtH Kirchner

Abstract

In the present study, immunological alterations were investigated as one possible factor contributing towards the pathogenesis of schizophrenia. Specifically cellular changes, deviating cytokine production and interfering variables were studied in order to improve our understanding of how these factors interact. 44 acutely ill schizophrenics were compared with matched healthy controls. Cell numbers were determined by flow cytometry and cytokine production by whole blood assay and ELISA. A criss-cross technique was employed for the assessment of interfering serum factors. Cell counts for leukocytes, lymphocytes, pan T cells, activated T cells and the absolute B cell count of the schizophrenic patients were all within normal limits. The absolute and relative monocyte counts, the number of IL-2 receptor carrying T cells and the relative B cell count were slightly elevated. IL-2 and IFN-gamma production were increased while IL-10 production, the sIL-2R and cortisol levels remained unchanged. No interfering serum factors were detected. The deficient production of TH-1 cytokines in schizophrenia is not due either to a changed number of immunocompetent cells or to a counterregulation of the TH-2 cytokine IL-10. Serum factors in in vit...Continue Reading

Citations

Oct 23, 2001·Depression and Anxiety·J LevineW Drevets
Jun 25, 2008·European Archives of Psychiatry and Clinical Neuroscience·Yuichiro WatanabeToshiyuki Someya
Jan 29, 2010·European Archives of Psychiatry and Clinical Neuroscience·Johann SteinerBernhard Bogerts
May 7, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sinead M Gibney, Hemmo A Drexhage
May 11, 2002·Current Psychiatry Reports·Dana C Perantie, E Sherwood Brown
Nov 19, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J K YaoD P van Kammen
Feb 13, 2001·Journal of Psychiatric Research·T PollmächerD Hinze-Selch
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Carlo L CazzulloMario Clerici
Mar 30, 2001·Schizophrenia Research·C L CazzulloM Clerici
Mar 9, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M MaesC A Altamura
Sep 18, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark H Rapaport, Catherine Bresee
Dec 4, 2010·Antioxidants & Redox Signaling·Jeffrey K Yao, Matcheri S Keshavan
Nov 27, 2007·Neuropsychobiology·Kyeong-Sae Na, Yong-Ku Kim
Aug 26, 2011·The Journal of ECT·Naren P RaoBangalore N Gangadhar
May 1, 2005·Expert Review of Clinical Immunology·Brian E Leonard
Dec 22, 2009·Expert Review of Neurotherapeutics·Roosmarijn C DrexhageHemmo A Drexhage
Jun 21, 2014·Schizophrenia Research·Hans-Gert BernsteinBernhard Bogerts
Nov 30, 2013·Biological Psychiatry·Veerle BerginkHemmo A Drexhage
Nov 28, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Norbert MüllerMarkus J Schwarz
Sep 15, 2012·Journal of Psychiatric Research·Milica BorovcaninMiodrag L Lukic
Oct 16, 2012·Biological Psychiatry·Brian J MillerAndrew Mellor
Oct 11, 2011·Brain, Behavior, and Immunity·Peggy SchneiderCornelius R Pawlak
Nov 17, 2007·Biological Psychiatry·Stéphane PotvinEdouard Kouassi
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku KimBrian E Leonard
Apr 4, 2006·Brain, Behavior, and Immunity·Lukasz DrzyzgaZbigniew S Herman
Jan 10, 2002·Brain, Behavior, and Immunity·M RothermundtT A Bayer
Jan 10, 2002·Brain, Behavior, and Immunity·M J SchwarzM Ackenheil
Jan 28, 2014·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Md Mamun Al-AminHasan Mahmud Reza
Mar 21, 2012·Psychiatry Research·Norbert MüllerMarkus J Schwarz
Dec 3, 2014·Psychiatry Research·Yousri El KissiJalel Boukadida
Jul 5, 2016·Frontiers in Cellular Neuroscience·Yuta TakahashiHiroaki Tomita
Aug 9, 2002·The Journal of International Medical Research·S EbrinçM Cetin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.