Immunological effects of behavioral activation with exercise in major depression: an exploratory randomized controlled trial

Translational Psychiatry
F EuteneuerW Rief

Abstract

Major depression (MD) is associated with peripheral inflammation and increased cardiovascular risk. Regular physical exercise can have anti-inflammatory effects. The present study examined whether behavioral activation with exercise affects inflammatory processes in MD. Ninety-eight patients with MD were randomly assigned to cognitive-behavioral therapy (CBT) emphasizing exercise during behavioral activation (CBT-E), CBT with pleasurable low-energy activities as an active control condition (CBT-C) or a passive waiting list control group (WL). Plasma levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, lipopolysaccharide (LPS)-stimulated IL-6 production, and blood immune cell counts were analyzed at baseline and weeks 8 (post-behavioral activation) and 16 (post-treatment). Thirty non-depressed age- and sex-matched controls were included to examine potential immunological alterations in MD at baseline. Patients with MD exhibited higher levels of CRP, higher neutrophil and monocyte counts, lower IL-10 levels and reduced LPS-stimulated IL-6 production compared to controls (P<0.001-0.045). Multilevel modeling indicated that CBT-E was associated with increased anti-inflammatory IL-10 at weeks 8 and 16 compared to CBT-C and ...Continue Reading

Associated Clinical Trials

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Citations

Jul 2, 2019·Psychological Medicine·Emanuele Felice OsimoGolam M Khandaker
Mar 28, 2020·Journal of Medical Internet Research·Lena JelinekBarbara Cludius
Aug 6, 2020·International Journal of Environmental Research and Public Health·Martino Belvederi MurriLuigi Grassi
Jan 14, 2021·Health & Social Care in the Community·Katarzyna K MachaczekScott Weich
Dec 2, 2020·Annual Review of Medicine·Patrick J Smith, Rhonda M Merwin
Jul 3, 2021·International Journal of Environmental Research and Public Health·Heidrun Lioba WunramOliver Fricke

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
flow cytometry
ELISA

Software Mentioned

BD FACSDiva
Cognitive Behavioral Analysis System of Psychotherapy
SPSS

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