Abstract
We have investigated the effects on the immune system, and especially on the induction of autoimmunity, of treatment of mice with recombinant IFN-gamma in vivo by several protocols. Neither antichromatin nor Coombs autoantibody was observed. The spleens of the treated animals enlarged two fold, despite a dramatic decrease in numbers of Thy-1+ spleen cells and a smaller decrease in surface Ig+ spleen cells. This was correlated with a markedly diminished Con A response and moderately reduced LPS response. On the other hand, the numbers of IgG secreting cells were augmented in the spleens of treated mice. In addition, IFN-gamma-injected mice lost weight and became anemic. This study shows that, although IFN-gamma-injected in vivo leads to severe changes in the murine immune system, it is not responsible by itself for the induction of autoimmunity.
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