Immunological evaluation of personalized peptide vaccination monotherapy in patients with castration-resistant prostate cancer

Cancer Science
Hirotsugu UemuraKyogo Itoh

Abstract

We previously reported that personalized peptide vaccine (PPV) therapy in combination with leutenizing hormone-releasing hormone (LH-RH) analog and estramustine phosphate in certain cases is safe and capable of inducing both immune responses and clinical responses for metastatic castration-resistant prostate cancer (CRPC) patients. In the present study, PPV monotherapy was given to CRPC patients. Twenty-three patients with metastatic CRPC were treated with PPV without any additional treatment modalities, including LH-RH analogs. Samples were analyzed for peptide-specific cytotoxic T-lymphocyte (CTL) precursor analysis and peptide-reactive IgG. Toxicity and immunological and clinical responses were assessed on a three-monthly basis. Seventeen patients were available for immunological and clinical evaluation. The vaccines were well tolerated, with grade 3 erythema at injection sites in only one patient. Augmentation of CTL or IgG responses to at least one of the peptides was observed in six of 17 (35%) and 15 of 17 (88%) patients tested, respectively. Among 57 peptides used, 9 and 36 peptides induced CTL and IgG responses, respectively. Delayed-type hypersensitivity reaction was observed in eight of 17 patients. More than 30% pro...Continue Reading

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Citations

May 25, 2011·Nature Reviews. Clinical Oncology·Giuseppe Di LorenzoPhilip W Kantoff
Nov 16, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·David S FinleyJean B Dekernion
Dec 25, 2012·Oncoimmunology·Erika VacchelliLorenzo Galluzzi
Jun 1, 2017·Nature Reviews. Urology·Takahiro KimuraHirotsugu Uemura
May 24, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Hirokazu MatsushitaYoshihiro Wada
Aug 24, 2012·Expert Review of Vaccines·David M Lubaroff

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