Immunological evidence for the occurrence of luteinizing hormone-releasing factor and the alpha-subunit of glycoprotein hormones in carcinoid tumors

The Journal of Clinical Endocrinology and Metabolism
T Wahlström, M Seppälä

Abstract

The immunoperoxidase technique was used to identify LRF and glycoprotein hormones or their subunits in 22 carcinoid tumors of various origins. All tumors were positive for both LRF and the alpha-subunit, whereas stainings with antisera against the beta-subunits of CG, LH, FSH, and TSH were negative. The binding of LRF and the alpha-subunit within the same malignant tissue raises the possibility of a functional relationship between the two.

Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·J HustinP Franchimont
Feb 1, 1985·Clinics in Endocrinology and Metabolism·A de Bustros, S B Baylin
Jul 29, 1983·Biochemical and Biophysical Research Communications·R PopkinH M Fraser
Jul 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S TanakaK Wakabayashi
Jan 1, 1983·Annals of the New York Academy of Sciences·M SeppäläH Bohn
Oct 1, 1984·British Journal of Obstetrics and Gynaecology·E M RutanenM Seppälä

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