Immunological features in pediatric patients with recurrent and severe infection: Identification of Primary Immunodeficiency Diseases in Merida, Venezuela

Allergologia et immunopathologia
N A LinaresS Salmen

Abstract

Primary immunodeficiency diseases (PIDs) are disorders associated mainly with recurrent and severe infection and an increase in susceptibility to autoimmune conditions and cancer. In Venezuela, PIDs are underdiagnosed and there is usually a delay in their diagnosis. Hence there are no data concerning the frequency and type of PIDs that occur. The aim of this study was to identify and quantify the types of PIDs that occur in Merida, a population within Venezuela. Following an informative program designed to alert local health professionals to the warning signs for PIDs, patients with a history of recurrent infections were referred to the Instituto de Inmunologia Clinica, Universidad de Los Andes. During the three-year period January 2014 to January 2017, thirty-two cases of PIDs were identified in pediatric patients, and 17 different types of PIDs, were identified. Predominantly antibody deficiencies were most frequent (40.6%), followed by immunodeficiencies affecting cellular and humoral immunity (21.8%), congenital defects of phagocyte (18.7%), CID with associated or syndromic features (9.3%), defects in intrinsic and innate immunity (6.4%) and diseases of immune dysregulation (3.2%). These results have important implications ...Continue Reading

References

Oct 3, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B WalzogP Gaehtgens
Dec 28, 2006·Journal of Clinical Immunology·Lily E LeivaUNKNOWN Latin American Group for Primary Immunodeficiency Diseases
Jun 20, 2007·Journal of Clinical Immunology·J M Boyle, R H Buckley
Jul 14, 2007·International Journal of Immunogenetics·O Kopecký, S Lukesová
Mar 24, 2009·Annual Review of Immunology·Mary Ellen ConleyDario Campana
Sep 25, 2010·The Journal of Allergy and Clinical Immunology·Chaim M RoifmanNigel Sharfe
Jul 27, 2011·Journal of Clinical Immunology·Fatemeh FattahiMostafa Moin
Dec 2, 2011·Annals of the New York Academy of Sciences·Peter D Arkwright, Andrew R Gennery
Dec 15, 2011·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Christine McCusker, Richard Warrington
Aug 1, 2012·Journal of Clinical Immunology·Ahmed Aziz BousfihaLaurent Abel
Jan 4, 2013·The World Allergy Organization Journal·Efren L RaelJonathan J McClain
Jan 26, 2013·Paediatric Respiratory Reviews·Maria Francesca Patria, Susanna Esposito
Jun 26, 2013·Clinical Reviews in Allergy & Immunology·Nashmia Qamar, Ramsay L Fuleihan
Mar 25, 2014·Journal of Clinical Immunology·Asghar AghamohammadiNima Rezaei
Dec 4, 2014·Current Opinion in Hematology·Susan Farmand, Mikael Sundin
Aug 4, 2015·Annals of the New York Academy of Sciences·Emilia CirilloClaudio Pignata
Sep 13, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Olufolakemi AweMark H Kaplan
Oct 12, 2015·Immunology and Allergy Clinics of North America·Nikita Raje, Chitra Dinakar
Feb 24, 2016·Journal of Clinical Immunology·Aristoteles Alvarez-CardonaFrancisco J Espinosa-Rosales
Nov 1, 2016·Expert Review of Clinical Immunology·Beatriz Costa-CarvalhoGesmar Segundo
Jan 4, 2017·The Journal of Allergy and Clinical Immunology·Elena E PerezMark Ballow
Mar 16, 2017·Frontiers in Pediatrics·Victoria R DimitriadesAlexandra F Freeman
Dec 12, 2017·Journal of Clinical Immunology·Aziz BousfihaKathleen E Sullivan

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