PMID: 16512356Mar 4, 2006Paper

Immunological findings in autism

International Review of Neurobiology
Hari Har Parshad Cohly, Asit Panja

Abstract

The immunopathogenesis of autism is presented schematically in Fig. 1. Two main immune dysfunctions in autism are immune regulation involving pro-inflammatory cytokines and autoimmunity. Mercury and an infectious agent like the measles virus are currently two main candidate environmental triggers for immune dysfunction in autism. Genetically immune dysfunction in autism involves the MHC region, as this is an immunologic gene cluster whose gene products are Class I, II, and III molecules. Class I and II molecules are associated with antigen presentation. The antigen in virus infection initiated by the virus particle itself while the cytokine production and inflammatory mediators are due to the response to the putative antigen in question. The cell-mediated immunity is impaired as evidenced by low numbers of CD4 cells and a concomitant T-cell polarity with an imbalance of Th1/Th2 subsets toward Th2. Impaired humoral immunity on the other hand is evidenced by decreased IgA causing poor gut protection. Studies showing elevated brain specific antibodies in autism support an autoimmune mechanism. Viruses may initiate the process but the subsequent activation of cytokines is the damaging factor associated with autism. Virus specific a...Continue Reading

Citations

Sep 30, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Rodney R Dietert, Janice M Dietert
Dec 17, 2008·Journal of Child Neurology·Gehan Ahmed MostafaMohamed Farouk El-Sayed
Oct 20, 2010·Expert Opinion on Therapeutic Targets·Kristi-Ann VillagonzaloMichael Berk
Jan 1, 2008·Clinical Medicine. Pathology·Timothy John Watts
Feb 15, 2012·Glia·Eleonora AronicaAnnamaria Vezzani
Jan 1, 2011·Emerging Health Threats Journal·Rodney R DietertJamie C Dewitt
Apr 10, 2014·Biomarkers in Medicine·Nadra E Elamin, Laila Y Al-Ayadhi
Apr 23, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Adrien A EshraghiDustin Lang
Aug 9, 2015·American Journal of Clinical Dermatology·Lucia BilleciSebastiano Gangemi
Jun 19, 2016·The Australian and New Zealand Journal of Psychiatry·Olivia M DeanMichael Berk
Jun 15, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·José Manuel López-CachoBlanca Cárdaba
Jan 6, 2017·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Faheem MaqboolMohammad Abdollahi
Nov 9, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Janet K Kern, Anne M Jones
Nov 1, 2007·Neuropathology and Applied Neurobiology·C Schmitz, P Rezaie
Sep 17, 2008·Journal of Clinical Psychopharmacology·Theoharis C Theoharides, Robert Doyle
Jul 14, 2010·International Journal of Environmental Research and Public Health·Nataliya KostyukHari H Cohly
Oct 2, 2009·Toxicology and Industrial Health·Kaye H KilburnNina B Immers
Aug 29, 2009·Journal of Child Neurology·Gehan A MostafaNermeen R Fouad
Jun 13, 2012·Cellular Microbiology·Bor Luen Tang
Aug 6, 2011·Nature Medicine·Abhay Sharma
May 13, 2011·Epilepsia·Eleonora Aronica, Peter B Crino
Jul 30, 2011·PloS One·Yong HeoDavid A Lawrence
Jan 1, 2012·Journal of Central Nervous System Disease·Hideo MatsuzakiNorio Mori
Aug 18, 2012·Journal of Neuroinflammation·Gehan A Mostafa, Laila Y Al-Ayadhi
Jun 21, 2013·Journal of Neuroinflammation·Laila Yousef Al-Ayadhi, Gehan Ahmed Mostafa
Feb 5, 2014·Dermato-endocrinology·John J Cannell, William B Grant
Nov 27, 2014·Family Practice·Michelle A M M van TongerlooAntoine L M Lagro-Janssen
Sep 18, 2013·European Child & Adolescent Psychiatry·Maria Dorota MajewskaPaweł Mierzejewski
Aug 17, 2016·Autism Research : Official Journal of the International Society for Autism Research·Daniel S TyleeStephen J Glatt

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