Immunological function of thymoma and pathogenesis of paraneoplastic myasthenia gravis.

General Thoracic and Cardiovascular Surgery
Meinoshin OkumuraYoshiki Sawa

Abstract

Thymoma and thymic carcinoma are the representative tumors arising from the thymic epithelium. Thymoma is well known for association with autoimmune diseases including myasthenia gravis, suggesting its biological activity. Herein, recent progress in research of thymoma is reviewed with reference to its immunological function. Myasthenia gravis is frequently associated with WHO type B1 and B2 thymomas. These types of thymomas hold a significant number of CD4(+)CD8(+) double-positive T cells, and at the same time, the neoplastic epithelial cells express HLA-DR molecules at a slightly reduced level compared with the normal thymus. The impaired expression of HLA-DR molecules in neoplastic epithelial cells of thymomas possibly affects positive selection of CD4(+)CD8(-) single-positive T cells and may result in alteration of its repertoire. The function of thymoma neoplastic cells as the cortical epithelium of the thymus and the morphological resemblance of thymomas to the cortex suggest that thymoma is of cortical epithelial origin; this might imply that thymoma lacks the functional medulla where professional antigen-presenting cells are engaged in negative selection. These findings suggest that thymoma generates autoreactive T cell...Continue Reading

References

Jan 1, 1987·Annual Review of Immunology·B AdkinsG J Spangrude
Jan 1, 1988·Advances in Immunology·J LindstromY Fujii
Aug 1, 1994·Immunology Today·P G Ashton-Rickardt, S Tonegawa
Apr 1, 1994·Current Opinion in Immunology·K A HogquistM J Bevan
Oct 15, 1993·Cellular Immunology·Y TakeuchiH Matsuda
Jan 1, 1996·Annual Review of Immunology·B MachW Reith
Mar 1, 1997·Archives of Histology and Cytology·H K Müller-HermelinkA Marx
Jan 1, 1997·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M InoueR Shirakura
Sep 23, 1998·Clinical Immunology and Immunopathology·M InoueH Matsuda
Aug 26, 1999·The British Journal of Ophthalmology·J M MAcKENZIE
Dec 12, 2001·The Journal of Surgical Research·M OkumuraH Matsuda
May 27, 2005·The Journal of Surgical Research·Keiji InadaHikaru Matsuda

❮ Previous
Next ❯

Citations

May 7, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Utano Tomaru, Masanori Kasahara
Jan 29, 2010·Surgery Today·Meinoshin OkumuraHiroyuki Shiono
Sep 6, 2012·Surgery Today·Yoshitaka Fujii
Feb 10, 2009·Current Treatment Options in Oncology·Robert P Nelson, Robert M Pascuzzi
Feb 15, 2011·Cellular & Molecular Immunology·Shahar ShellyYehuda Shoenfeld
Nov 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronan J KellyGiuseppe Giaccone
Sep 1, 2010·Journal of Toxicologic Pathology·Yuri KotaniMinoru Tsuchitani
Jul 1, 2014·Nature Genetics·Iacopo PetriniGiuseppe Giaccone
Oct 11, 2014·General Thoracic and Cardiovascular Surgery·Takahiro KarasakiJun Nakajima
Apr 15, 2015·Autoimmunity·Amelia EvoliEmanuela Bartoccioni
Oct 5, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Diana K LeeRonald E Gress
Jan 29, 2016·Critical Reviews in Oncology/hematology·Marta ScorsettiMarina Chiara Garassino
Sep 4, 2013·La Presse médicale·Valentina PoloBenjamin Besse
Sep 27, 2015·Autoimmunity Reviews·C BernardP Sève
Jul 30, 2010·International Journal of Cancer. Journal International Du Cancer·Shahinaz M GadallaGiuseppe Giaccone
Sep 17, 2011·Muscle & Nerve·Paola CavalcanteRenato Mantegazza
Jan 15, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Pier Luigi FilossoFederico Venuta
Mar 22, 2015·Clinical and Experimental Medicine·Alexandra Papoudou-BaiPanagiotis Kanavaros
May 21, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomohiro MurakawaJun Nakajima
Mar 31, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·N IgaK Kabashima
Mar 31, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Pier Luigi FilossoMarco Lucchi
Aug 8, 2018·Future Oncology·Vivek KumarAbhinav Binod Chandra
Mar 23, 2010·The American Journal of Surgical Pathology·Marc HartertChristian-Friedrich Vahl
May 25, 2013·Journal of Clinical Neuromuscular Disease·G Z Huang, Y L Lo
Nov 6, 2009·Autoimmunity·Toshiteru TokunagaMeinoshin Okumura
Feb 7, 2017·Journal of the American Veterinary Medical Association·Cheryl A Moller, Hannah Bender
Jul 9, 2020·Case Reports in Pulmonology·Saumil DatarHoriana Grosu
Apr 13, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hyun-Sung LeeBryan M Burt
Jan 9, 2021·Immunology Letters·Kissy Guevara-HoyerSilvia Sánchez-Ramón
Nov 15, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomoyuki HishidaMeinoshin Okumura
Mar 7, 2021·Muscle & Nerve·Deepak MenonVera Bril
Jun 2, 2021·General Thoracic and Cardiovascular Surgery·Naota OkabeHiroshi Kamma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Annals of the New York Academy of Sciences
Alexander MarxPhilipp Ströbel
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Marco LucchiAlfredo Mussi
© 2022 Meta ULC. All rights reserved