Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect

Trends in Immunology
María E Rodríguez-RuizSandra Demaria

Abstract

Radiotherapy has been used for more than a hundred years as a local tumor treatment. The occurrence of systemic antitumor effects manifesting as regression of tumors outside of the irradiated field (abscopal effect) was occasionally observed but deemed too rare and unpredictable to be a therapeutic goal. This has changed with the advent of immunotherapy. Remarkable systemic effects have been observed in patients receiving radiotherapy to control tumors that were progressing during immune checkpoint blockade, stimulating interest in using radiation to overcome primary and acquired cancer resistance to immunotherapy. Here, we review the immunological mechanisms that are responsible for the ability of focal radiation to promote antitumor T cell responses that mediate tumor rejection and, in some cases, result in systemic effects.

Citations

Sep 20, 2019·Healthcare·Masahiro KagabuTsukasa Baba
Jul 12, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Igor Shuryak
Feb 27, 2020·The British Journal of Radiology·Sandra Demaria, Silvia C Formenti
Feb 23, 2020·International Journal of Cancer. Journal International Du Cancer·Elisa Funck-BrentanoPhilippe Saiag
Jan 9, 2020·Journal of Radiation Research·Eunji KimChul Koo Cho
Apr 2, 2020·International Journal of Molecular Sciences·Masahiro KagabuTsukasa Baba
Apr 6, 2020·The FEBS Journal·Amanda J OliverClare Y Slaney
Jun 10, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shalini K Vinod, Eric Hau
May 29, 2020·The British Journal of Radiology·Martin Kery, Ioanna Papandreou
Jun 26, 2020·Journal for Immunotherapy of Cancer·Simon P KeamPaul J Neeson
Jul 20, 2020·CA: a Cancer Journal for Clinicians·Aaron J GrossbergCharles R Thomas
Sep 27, 2019·Nature Reviews. Drug Discovery·Claire Vanpouille-BoxLorenzo Galluzzi
Apr 30, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carolien BeylsJeroen Dekervel
Oct 12, 2019·The Journal of Experimental Medicine·Xiaodong JiangAkiko Iwasaki
Jan 30, 2019·Frontiers in Immunology·Ruben S A GoedegebuureVictor L J L Thijssen
Jun 11, 2019·Frontiers in Oncology·Ondrej PalataIrena Adkins
Apr 18, 2020·BMC Immunology·Samantha S BeaufordCharlie Garnett-Benson
Apr 27, 2019·Frontiers in Immunology·Simone de LeveVerena Jendrossek
Jul 12, 2019·JAMA Oncology·Joshua Walker, Billy W Loo
Jul 3, 2019·International Journal of Molecular Sciences·Magdalena Jarosz-BiejNatalia Kułach
Jul 10, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Rudolf M HuberAmanda Tufman
Oct 9, 2019·Nature Reviews. Clinical Oncology·Oliver KeppGuido Kroemer
Sep 15, 2020·Therapeutic Advances in Medical Oncology·Harry J HanRahul Aggarwal
Feb 23, 2019·Nature Reviews. Disease Primers·Dirk De RuysscherFiona Hegi-Johnson
Dec 18, 2019·Cellular & Molecular Immunology·Zhida LiuYang-Xin Fu
Apr 2, 2020·Nature Immunology·Chuanhui HanYang-Xin Fu
Jun 26, 2020·British Journal of Cancer·Elisabeth DaguenetNicolas Magné
Sep 16, 2020·Cardiovascular and Interventional Radiology·Julien EdelineEtienne Garin
Aug 28, 2020·Frontiers in Immunology·Claire C BanielZachary S Morris
Mar 30, 2019·Journal for Immunotherapy of Cancer·Christine Ménétrier-CauxChristophe Caux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.