Immunological monitoring for prediction of clinical response to antitumor vaccine therapy

Oncotarget
Irina N MikhaylovaLev V Demidov

Abstract

Immunotherapy has shown promising results in a variety of cancers, including melanoma. However, the responses to therapy are usually heterogeneous, and understanding the factors affecting clinical outcome is still not achieved. Here, we show that immunological monitoring of the vaccine therapy for melanoma patients may help to predict the clinical course of the disease. We studied cytokine profile of cellular Th1 (IL-2, IL-12, IFN-γ) and humoral Th2 (IL-4, IL-10) immune response, vascular endothelial growth factor (VEGFA), transforming growth factor-β 2 (TGF-β 2), S100 protein (S100A1B and S100BB), adhesion molecule CD44 and serum cytokines β2-microglobulin to analyze different peripheral blood mononuclear cell subpopuations of patients treated with dendritic vaccines and/or cyclophosphamide in melanoma patients in the course of adjuvant treatment. The obtained data indicate predominance of cellular immunity in the first adjuvant group of patients with durable time to progression and shift to humoral with low cellular immunity in patients with short-term period to progression (increased levels of IL-4 and IL- 10). Beta-2 microglobulin was differentially expressed in adjuvant subgroups: its higher levels correlated with shorter ...Continue Reading

References

Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Dec 24, 2002·Trends in Immunology·Simone MocellinFrancesco M Marincola
Jul 29, 2003·Melanoma Research·Ugo BottoniStefano Calvieri
Aug 2, 2003·Journal of the American Academy of Dermatology·Pedro RedondoMartin C Mihm
May 29, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M L LevittT L Whiteside
Mar 23, 2005·Cancer Immunology, Immunotherapy : CII·Janet M D PlateJules E Harris
Oct 6, 2005·Journal of the National Cancer Institute·Pierpaolo CorrealeMaria Grazia Cusi
Mar 23, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander GelbardJames W Hodge
Dec 26, 2006·Nature Medicine·Michel ObeidGuido Kroemer
Apr 18, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zoya R YurkovetskyAnna E Lokshin
May 4, 2007·The Journal of Clinical Investigation·Ilona Gutcher, Burkhard Becher
Dec 22, 2007·Nature Reviews. Immunology·Laurence ZitvogelGuido Kroemer
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Apostolia-Maria TsimberidouElihu H Estey
Jun 5, 2008·The Journal of Clinical Investigation·Laurence ZitvogelGuido Kroemer
Oct 11, 2008·American Journal of Clinical Oncology·Raquel AndrésAlejandro Tres
Feb 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wendy K NevalaUNKNOWN Melanoma Study Group of the Mayo Clinic Cancer Center
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
May 11, 2010·Journal of Cancer Research and Clinical Oncology·Maja A HofmannUwe Trefzer
May 21, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Madeline M Fort, Padma K Narayanan
Aug 20, 2011·Cancer Immunology, Immunotherapy : CII·Mizue TeraiTakami Sato
Jan 14, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S Kruijff, H J Hoekstra
Oct 20, 2012·Nature Reviews. Immunology·Susan M Kaech, Weiguo Cui
May 9, 2013·Frontiers in Oncology·Brian M Olson, Douglas G McNeel
Jun 21, 2013·International Journal of Cancer. Journal International Du Cancer·Ana B del CampoNatalia Aptsiauri
Jul 24, 2014·Immunology·Nicola L D Smith, David W Denning

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Citations

Jun 25, 2020·International Journal of Molecular Sciences·Gaia GiannoneGiorgio Valabrega

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
transfection
ELISA
flow cytometry

Software Mentioned

STATISTICA
BD FACSDiva

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