Immunological monitoring of posttransplant allograft sensitization following living related donor renal transplantation

Transplantation Proceedings
Arundhati PanigrahiNarinder K Mehra

Abstract

A better understanding of the immunobiological processes and predictors of graft rejection holds promise for development of new therapeutic strategies and also for individualization of immunosuppression. The objective of this study was to analyze the clinical relevance of immune parameters, such as recipient sensitization status, donor-specific antibodies, and anti-HLA antibodies, which are major predictors of graft outcome following renal transplantation. Sera from 264 renal recipients at different posttransplant period were included for detection of anti-donor antibodies (by flowcytometry); anti-HLA, antibody (by ELISA), and panel-reactive antibodies (PRA) by complement-dependent cytotoxicity (CDC) methods. Graft survival was analyzed in relation to posttransplant PRA at 2 years follow-up time: overall survival was significantly compromised in the highly sensitized group (group III) compared to the other two groups (overall chi2 = 24.20, P = 5.5 x 10(-06)). Flow cytometric cross-matches revealed the presence of anti-donor class I antibodies (T+) in 39 patients who had a poor graft survival of 51% compared with 85% survival in 225 antibody-negative patients. (chi2 = 22.260, P = 2.381 x 10(-.06)). Further analysis was performed...Continue Reading

References

Dec 1, 1981·Transplantation·G J CerilliM E DeFrancis
Mar 31, 1999·Immunology Today·D S Gould, H Auchincloss
Aug 1, 2000·Kidney International·D W Gjertson, J M Cecka
May 1, 2002·Transplantation·Caner Süsal, Gerhard Opelz
Apr 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gema Fernández-FresnedoManuel Arias
Oct 8, 2003·Transplantation Proceedings·J SieńkoA Mizerski

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Citations

Feb 10, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jeremy YangRobert Gajarski
Sep 11, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H S EngG R Russ
Jul 30, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L K HendersonJ R Chapman
Aug 3, 2013·American Journal of Reproductive Immunology : AJRI·Roberto RomeroTinnakorn Chaiworapongsa

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