PMID: 109389Jan 1, 1978

Immunological nature of genetic resistance of mice to herpes simplex virus type 1 infection

IARC Scientific Publications
C Lopez

Abstract

Treatment of mice genetically resistant to HSV-1 with agents which impair T-cell or macrophage function markedly diminished resistance. Bone marrow transplantation of genetically susceptible mice with marrow from resistant F1 mice produced chimeras resistant to HSV-1. Resistance thus appears to be immunological in nature. Striking similarities were found between resistance to HSV-1 and allogeneic resistance.

Related Concepts

Ir Genes
Graft Rejection
Herpes Simplex Infections
Therapeutic Immunosuppression
Macrophage
Mice, Inbred A
Mice, Inbred C57BL
Radiation Chimera
T-Lymphocyte
Transplantation, Homologous

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