Immunological network analysis in HPV associated head and neck squamous cancer and implications for disease prognosis

Molecular Immunology
Xiaohang ChenFengmin Zhang

Abstract

Human papillomavirus-positive (HPV+) head and neck squamous cell cancer (HNSCC) exhibits a better prognosis than HPV-negative (HPV-) HNSCC. This difference may in part be due to enhanced immune activation in the HPV+ HNSCC tumor microenvironment. To characterize differences in immune activation between HPV+ and HPV- HNSCC tumors, we identified and annotated differentially expressed genes based upon mRNA expression data from The Cancer Genome Atlas (TCGA). Immune network between immune cells and cytokines was constructed by using single sample Gene Set Enrichment Analysis and conditional mutual information. Multivariate Cox regression analysis was used to determine the prognostic value of immune microenvironment characterization. A total of 1673 differentially expressed genes were functionally annotated. We found that genes upregulated in HPV+ HNSCC are enriched in immune-associated processes. And the up-regulated gene sets were validated by Gene Set Enrichment Analysis. The microenvironment of HPV+ HNSCC exhibited greater numbers of infiltrating B and T cells and fewer neutrophils than HPV- HNSCC. These findings were validated by two independent datasets in the Gene Expression Omnibus (GEO) database. Further analyses of T cell ...Continue Reading

Citations

Jun 2, 2020·International Journal of Cancer. Journal International Du Cancer·Nicole D FacompreDevraj Basu
Jul 1, 2020·Current Oncology Reports·Niels E WondergemRieneke van de Ven
Apr 20, 2019·Frontiers in Immunology·Hao-Fan WangXin-Hua Liang
Dec 19, 2019·Frontiers in Immunology·Mine Özcan-WahlbrinkAngelika B Riemer
Jun 5, 2020·Journal of Experimental & Clinical Cancer Research : CR·Ming-Xin CaoYa-Ling Tang
Jan 29, 2020·Cancers of the Head & Neck·Mara S SerafiniCarlo Resteghini
Nov 25, 2020·The Journal of Clinical Investigation·Dayson MoreiraMarcin Kortylewski
Dec 22, 2020·Frontiers in Cellular and Infection Microbiology·Nikita AggarwalAlok C Bharti
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Annette AffolterNicole Rotter
Jul 9, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Juhyun OhRalph Weissleder
Oct 17, 2021·International Journal of Cancer. Journal International Du Cancer·Xinyi LiuXiaowei Wang

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