PMID: 8962614Apr 1, 1996Paper

Immunological outcome measures

The European Respiratory Journal. Supplement
B Björkstén

Abstract

The determination of immunoglobulin E (IgE) antibodies by one of several laboratory tests, by skin-prick tests or by appropriate challenge procedures is useful either to identify atopic individuals or as outcome predictors in wheezy children. The determination of allergen specific antibodies of other isotypes, e.g. immunoglobulin G (IgG) and IgG subclass antibodies in serum, secretory immunoglobulin A (IgA) and various immune complexes, have not been confirmed as clinically useful tools for this purpose. Immune responses in atopic and nonatopic individuals differ in several other respects, e.g. they express somewhat different lymphocyte and cytokine profiles, as well as cellular immune responses. At present, none of these differences can be employed clinically, however, and the determinations are still research tools. A reduction in exposure to allergens is associated with fewer symptoms and improved lung function in sensitized individuals. There are also indications that reduced exposure to allergens in early infancy may prevent, or at least delay, sensitization and wheezing in atopic children. Determination of exposure to major indoor allergens, e.g. house dust mite, cat and cockroach allergens, are, therefore, of value in th...Continue Reading

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Related Papers

Acta Paediatrica Taiwanica = Taiwan Er Ke Yi Xue Hui Za Zhi
Kuo-Wei Yeh
Pediatric Clinics of North America
A L Duff, T A Platts-Mills
© 2021 Meta ULC. All rights reserved