Immunological pathogenesis and treatment of systemic lupus erythematosus.

World Journal of Pediatrics : WJP
Lu PanSi-Rui Yang

Abstract

Systemic lupus erythematosis (SLE) is a complex and clinically heterogeneous autoimmune disease. A variety of immunological defects contribute to SLE, including dysregulated innate and adaptive immune response. A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science is predicted to enable accelerated progress towards improved SLE-personalized approaches to treatment. The aim of this review was to clarify the immunological pathogenesis and treatment of SLE. Literature reviews and original research articles were collected from database, including PubMed and Wanfang. Relevant articles about SLE were included. Breakdown of self-tolerance is the main pathogenesis of SLE. The innate and adaptive immune networks are interlinked with each other through cytokines, complements, immune complexes and kinases of the intracellular machinery. Treatments targeted at possible targets of immunity have been assessed in clinical trials. Most of them did not show better safety and efficacy than traditional treatments. However, novel targeting treatments are still being explored. Dysregulated immune response plays a critical role in SLE, including innate immunity and adaptive immunity. ...Continue Reading

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Citations

Sep 25, 2019·Current Pharmaceutical Biotechnology·Tianzhong LiMengsu Yang
Jul 24, 2020·Expert Opinion on Investigational Drugs·Jacqueline L Paredes, Timothy B Niewold
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Mar 20, 2021·Stem Cell Research & Therapy·Alexander MarkovAli Hassanzadeh
Jul 9, 2021·Immunotherapy·Maciej GonciarzWitold Owczarek
Sep 1, 2021·Drugs·Sohita Dhillon

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Methods Mentioned

BETA
ubiquitination

Clinical Trials Mentioned

NCT02446899
NCT02547922
NCT02804763

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